The Effects of dexmedetomidine on alterations of renal function following renal I/R-induced injury. Serum creatinine (A) and plasma urea (B) were measured to assess the renoprotective effect of dexmedetomidine against renal I/R injury in the sham, IRI, DMSO, Atip, DEX and AG490 groups. Data were represented as mean ± SEM (n = 8). *P < 0.05 and **P < 0.01 vs. the sham group. #P < 0.05 vs. the IRI and DMSO groups. $P < 0.05 vs. the DEX group.