Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis

Table 3 Univariate and multivariate Cox regression analysis of different prognostic variables in NPC patients

Variable	Subset	HR (95%) CI	P-value
Univariate analysis (N=178)
PTK6 expression	High versus Low	3.519 (1.918-6.458)	<0.001^*
Age (years)	> 46 versus ≤ 46	2.046 (1.278-3.277)	0.003^*
Sex	Female versus Male	0.872 (0.512-1.485)	0.614
Metastasis	Yes versus No	4.735 (2.919-7.679)	<0.001^*
Local-regional relapse	Yes versus No	1.999 (1.129-3.539)	0.017^*
Tumor size	T1+T2 versus T3+T4	1.477 (0.872-2.502)	0.147
Lymphoid Nodal states	N0-1 versus N2-3	1.657 (1.072-2.672)	0.039^*
Clinical stage	I + II versus III + IV	4.599 (1.676-12.619)	0.003^*
WHO histological classification	NKDC versus NKUC	1.244 (0.404-3.834)	0.703
Multivariate analysis (N=178)
PTK6 expression	High versus Low	2.038 (1.051-3.951)	0.035^*
Age (years)	> 46 versus ≤ 46	1.900 (1.165-3.079)	0.010^*
Metastasis	Yes versus No	5.290 (3.122-8.962)	<0.001^*
Local-regional relapse	Yes versus No	2.427 (1.303-4.519)	0.005^*
Lymphoid Nodal states	N0-1 versus N2-3	1.372 (0.823-2.288)	0.225
Clinical stage	I + II versus III + IV	3.343 (1.057-10.574)	0.040^*

^*Statistically significant difference
Abbreviations PTK6 protein tyrosine kinase 6, NPC nasopharyngeal carcinoma, HR hazard ratio, CI confidence interval.

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