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Table 3 Univariate and multivariate Cox regression analysis of different prognostic variables in NPC patients

From: Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis

Variable Subset HR (95%) CI P-value
Univariate analysis (N=178)    
PTK6 expression High versus Low 3.519 (1.918-6.458) <0.001*
Age (years) > 46 versus ≤ 46 2.046 (1.278-3.277) 0.003*
Sex Female versus Male 0.872 (0.512-1.485) 0.614
Metastasis Yes versus No 4.735 (2.919-7.679) <0.001*
Local-regional relapse Yes versus No 1.999 (1.129-3.539) 0.017*
Tumor size T1+T2 versus T3+T4 1.477 (0.872-2.502) 0.147
Lymphoid Nodal states N0-1 versus N2-3 1.657 (1.072-2.672) 0.039*
Clinical stage I + II versus III + IV 4.599 (1.676-12.619) 0.003*
WHO histological classification NKDC versus NKUC 1.244 (0.404-3.834) 0.703
Multivariate analysis (N=178)    
PTK6 expression High versus Low 2.038 (1.051-3.951) 0.035*
Age (years) > 46 versus ≤ 46 1.900 (1.165-3.079) 0.010*
Metastasis Yes versus No 5.290 (3.122-8.962) <0.001*
Local-regional relapse Yes versus No 2.427 (1.303-4.519) 0.005*
Lymphoid Nodal states N0-1 versus N2-3 1.372 (0.823-2.288) 0.225
Clinical stage I + II versus III + IV 3.343 (1.057-10.574) 0.040*
  1. *Statistically significant difference
  2. Abbreviations PTK6 protein tyrosine kinase 6, NPC nasopharyngeal carcinoma, HR hazard ratio, CI confidence interval.