Skip to main content

Table 2 Fourteen SNPs identified by GWAS associated with prostate cancer risk in Tunisians

From: Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians

dbSNP ID

Chr

Gene

Allelea

Risk allele frequency

HetOR(95%CI)

P b

HomOR(95%CI)

P

Risk allele OR(95%CI)

P

    

Case

Control

      

Previous reported

          

rs1053005

17

STAT3

T/C

0.45

0.26

2.94(1.30-4.41)

4 × 10-3

4.22(1.84-9.69)

4 × 10-4

2.30(1.54-3.45)

4 × 10-5

rs8074524

17

STAT3

C/T

0.45

0.25

2.43(1.32-4.47)

4 × 10-3

5.05(2.14-12.0)

1 × 10-4

2.46(1.64-3.70)

1 × 10-5

rs3809758

17

STAT3

C/T

0.45

0.26

2.25(1.23-4.14)

8 × 10-3

4.41(1.90-10.2)

3 × 10-4

2.31(1.54-3.47)

4 × 10-5

Newly reported

         

rs7045455

9

SMARCA2

T/C

0.94

0.80

3.80(0.20-71.9)

0.2

12.5(0.70-222.6)

0.02

3.98(1.97-8.05)

4 × 10-5

rs12686439

9

SMARCA2

G/A

0.92

0.77

4.39(0.64-81.6)

0.16

13.2(0.74-234.5)

0.02

3.32(1.80-6.15)

7 × 10-5

rs10810919

9

SMARCA2

T/C

0.95

0.82

2.09(0.10-41.8)

0.35

9.14(0.50-167.8)

0.04

5.03(2.22-11.4)

2 × 10-5

rs10963533

9

SMARCA2

T/C

0.95

0.81

2.46(0.13-48.3)

0.31

9.30(0.51-170.9)

0.04

4.19(2.01-8.75)

5 × 10-5

rs10963540

9

SMARCA2

G/A

0.95

0.81

2.66(0.14-51.9)

0.28

11.0(0.61-198.6)

0.03

4.81(2.23-10.4)

2 × 10-5

rs12601982

17

STAT5A

A/G

0.35

0.17

2.27(1.25-4.14)

7 × 10-3

6.43(2.15-19.3)

3 × 10-3

2.61(1.67-4.07)

2 × 10-5

rs8078731

17

STAT3

A/T

0.32

0.16

2.06(1.10-3.84)

0.02

5.67(1.85-17.4)

1 × 10-3

2.47(1.55-3.93)

1 × 10-4

rs5750627

22

LOC646851

C/T

0.71

0.50

1.76(0.77-4.01)

0.17

4.50(1.98-10.3)

2 × 10-4

2.40(1.60-3.60)

2 × 10-5

rs6001173

22

LOC646851

C/T

0.70

0.50

1.84(0.81-4.18)

0.14

4.30(1.89-9.78)

3 × 10-4

2.32(1.54-3.49)

4 × 10-5

rs138702

22

SUN2

T/A

0.75

0.55

3.14(1.12-8.86)

0.02

6.59(2.33-18.4)

1 × 10-4

2.44(1.60-3.71)

3 × 10-5

rs138712

22

SUN2

A/G

0.74

0.54

2.54(0.96-6.72)

0.05

5.92(2.25-15.6)

1 × 10-4

2.47(1.63-3.76)

2 × 10-5

  1. Note: Chr, chromosome; OR, Odds ratio; CI, confidence interval; HetOR, odds ratio in heterozygote; HomOR, odds ratio in homozygote for risk allele (relative to homozygote for non-risk allele).
  2. a Reference allele/risk allele.
  3. b Bold font indicates that P value reaches the adjusted significant level (i.e., 0.05/14).