Figure 4
From: Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice
Involvement of IL-10 in tumor growth. (A and C) Suppression assay performed with TIL purified from melanoma (A) or ALCL (C). CFSE-labeled syngeneic splenocytes were in vitro stimulated with Con A and co-incubated with TIL in the presence or not of an anti-IL-10 mAb or its relative isotypic control. Data are expressed as percentage of replicating, CFSE+ cells; percentage of inhibition are indicated in parentheses. (B and D) Mean tumor dimensions in mice challenged after 21 days with either B16F10 melanoma (B) or VAC ALCL (D) cells and treated or not with an anti-IL-10 mAb or its relative isotypic control.