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Table 1 Correlation between the clinicopathologic characteristics and membranous, cytoplasmic and nuclear expression of β-catenin in 316 NSCLC patients

From: Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer

   MEMBRANOUS(n, %) CYTOPLASMIC(n, %) NUCLEAR(n, %)
Variables Cases Low(102) High(207) p a Low(176) High(133) p a Low(170) High(139) p a
Gender           
Male 134 42(31.3) 92(68.7) 0.586 74(55.2) 60(44.8) 0.590 73(54.5) 61(45.5) 0.868
Female 175 60(34.3) 115(65.7)   102(58.3) 73(41.7)   97(55.4) 78(44.6)  
Age (years)b           
<52 149 59(39.6) 90(60.4) 0.017 85(57.0) 64(43.0) 0.976 77(51.7) 72(48.3) 0.255
≥52 160 43(26.9) 117(73.1)   91(56.9) 69(43.1)   93(58.1) 67(41.9)  
Histologic subtype           
Squamous carcinoma 142 47(33.1) 95(66.9) 0.976 87(61.3) 55(38.7) 0.158 85(59.9) 57(40.1) 0.115
Adenocarcinoma 167 55(32.9) 119(67.1)   89(53.3) 78(46.7)   85(50.9) 82(49.1)  
Histologicalgrade           
Grade 1 126 34(27.0) 92(73.0) 0.032 75(59.5) 51(40.5) 0.644 83(65.9) 43(34.1) 0.001
Grade 2 112 36(32.1) 76(67.9)   60(53.6) 52(46.4)   59(52.7) 53(47.3)  
Grade 3 71 32(45.1) 39(54.9)   41(57.7) 30(42.3)   28(39.4) 43(60.6)  
T classification           
T1 71 23(32.4) 48(67.6) 0.069 43(60.6) 28(39.4) 0.349 40(56.3) 31(43.7) 0.727
T2 58 23(39.7) 35(60.3)   37(63.8) 21(36.2)   32(55.2) 26(44.8)  
T3 126 39(31.0) 87(69.0)   70(55.6) 56(44.4)   72(57.1) 54(42.9)  
T4 54 17(31.5) 37(68.5)   26(48.1) 28(51.9)   26(48.1) 28(51.9)  
Clinical stage           
I 108 35(32.4) 73(67.6) 0.818 62(57.4) 46(42.6) 0.957 56(51.9) 52(48.1) 0.689
II 81 29(35.8) 52(64.2)   45(55.6) 36(44.4)   45(55.6) 36(44.4)  
III 120 38(31.7) 82(68.3)   69(57.5) 51(42.5)   69(57.5) 51(42.5)  
  1. a Chi-square test.
  2. b Patients were divided according to the median values of age.