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Table 1 Correlation between the clinicopathologic characteristics and membranous, cytoplasmic and nuclear expression of β-catenin in 316 NSCLC patients
| MEMBRANOUS(n, %) | CYTOPLASMIC(n, %) | NUCLEAR(n, %) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables | Cases | Low(102) | High(207) | p a | Low(176) | High(133) | p a | Low(170) | High(139) | p a |
| Gender | ||||||||||
| Male | 134 | 42(31.3) | 92(68.7) | 0.586 | 74(55.2) | 60(44.8) | 0.590 | 73(54.5) | 61(45.5) | 0.868 |
| Female | 175 | 60(34.3) | 115(65.7) | 102(58.3) | 73(41.7) | 97(55.4) | 78(44.6) | |||
| Age (years)b | ||||||||||
| <52 | 149 | 59(39.6) | 90(60.4) | 0.017 | 85(57.0) | 64(43.0) | 0.976 | 77(51.7) | 72(48.3) | 0.255 |
| ≥52 | 160 | 43(26.9) | 117(73.1) | 91(56.9) | 69(43.1) | 93(58.1) | 67(41.9) | |||
| Histologic subtype | ||||||||||
| Squamous carcinoma | 142 | 47(33.1) | 95(66.9) | 0.976 | 87(61.3) | 55(38.7) | 0.158 | 85(59.9) | 57(40.1) | 0.115 |
| Adenocarcinoma | 167 | 55(32.9) | 119(67.1) | 89(53.3) | 78(46.7) | 85(50.9) | 82(49.1) | |||
| Histologicalgrade | ||||||||||
| Grade 1 | 126 | 34(27.0) | 92(73.0) | 0.032 | 75(59.5) | 51(40.5) | 0.644 | 83(65.9) | 43(34.1) | 0.001 |
| Grade 2 | 112 | 36(32.1) | 76(67.9) | 60(53.6) | 52(46.4) | 59(52.7) | 53(47.3) | |||
| Grade 3 | 71 | 32(45.1) | 39(54.9) | 41(57.7) | 30(42.3) | 28(39.4) | 43(60.6) | |||
| T classification | ||||||||||
| T1 | 71 | 23(32.4) | 48(67.6) | 0.069 | 43(60.6) | 28(39.4) | 0.349 | 40(56.3) | 31(43.7) | 0.727 |
| T2 | 58 | 23(39.7) | 35(60.3) | 37(63.8) | 21(36.2) | 32(55.2) | 26(44.8) | |||
| T3 | 126 | 39(31.0) | 87(69.0) | 70(55.6) | 56(44.4) | 72(57.1) | 54(42.9) | |||
| T4 | 54 | 17(31.5) | 37(68.5) | 26(48.1) | 28(51.9) | 26(48.1) | 28(51.9) | |||
| Clinical stage | ||||||||||
| I | 108 | 35(32.4) | 73(67.6) | 0.818 | 62(57.4) | 46(42.6) | 0.957 | 56(51.9) | 52(48.1) | 0.689 |
| II | 81 | 29(35.8) | 52(64.2) | 45(55.6) | 36(44.4) | 45(55.6) | 36(44.4) | |||
| III | 120 | 38(31.7) | 82(68.3) | 69(57.5) | 51(42.5) | 69(57.5) | 51(42.5) | |||
