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Table 1 Clinical characteristics of tumors and experiments in which corresponding xenografts were used

From: Origin of the vasculature supporting growth of primary patient tumor xenografts

Primary site description

ID#

Exp

Sex

Age

Histology description

Grade

Path T

Path N

Path M

AJCC stage path

Treatment prior to sample

Esophagus, lower third

12944

2

M

70

Ad, NOS

III

2

1

0

2B

no

Esophagus, lower third

13176

2

M

40

Ad, NOS

III

1

1

1

4

no

Ovary

13575

2

F

67

PSC

III

3C

0

0

3C

Carboplatin/Taxol

Esophagus

13618

2

nd

nd

nd

nd

nd

nd

nd

nd

nd

Ovary

13987

2

F

43

SSPC

III

3C

1

0

3C

no

Pleura, NOS

14967

4

M

70

Meso

nd

3

0

0

3

Radiation and chemotherapy (Alimta & cisplatin)

Pancreas, head of

15010

3

F

74

Inf Duct, NOS

II

3

1

0

2B

no

Pancreas, body of

15406

3

M

74

Inf Duct, NOS

II

2

0

0

1B

no

Kidney, NOS

15773

3

M

69

RCC, NOS

III

3A

0

1

4

no

Kidney, NOS

15818

3

F

57

RCC, Clear cell

III

1B

0

X

1

no

Lung, upper lobe

15946

3

F

73

SCC, NOS

III

2

0

0

1B

no

Pancreas, tail of

16096

3

M

66

Inf Duct, NOS

II

2

0

0

1B

no

Colon, ascending

16115

3

M

59

Ad, NOS

II

X

X

nd

nd

FOLFOX with Avastin

Kidney, NOS

16616

3

M

62

RCC, NOS

III

3B

0

0

3

no

Kidney, NOS

16692

2, 3

M

57

RCC, sarcomatoid

IV

3B

1

X

4

no

Kidney, NOS

16803

3

M

63

RCC, Clear cell

III

1A

X

X

1

no

Colon, ascending

16811

3

F

83

Ad, NOS

II

4

0

0

2B

no

Pancreas, head of

16870

3

F

31

Inf Duct, NOS

III

3

1

0

2B

no

Colon, Sigmoid, NOS

16879

3

F

76

Ad, NOS

II

3

0

0

2A

no

Pancreas, head of

17123

3

M

79

Ad, NOS

III

3

1

0

2B

no

Rectosigmoid junction

17224

2

F

52

Ad, NOS

II

3

1

1

4

no

Lung, lower lobe

17228

3

F

82

CSC

III

2

0

0

1B

no

Colon, ascending

17239

2

M

71

Ad, NOS

II

3

2

0

3C

no

Lung, upper lobe

17246

2, 3

M

53

Ad, NOS

III

3

0

0

2B

no

Lung, lower lobe

17291

1, 3

F

53

Pleomorphic ca

IV

3

0

nd

2B

no

Tonsillar pillar

17307

2

M

67

SCC, NOS

I

0

2B

1

4C

no

Rectosigmoid junction

17346

3

M

57

Ad, NOS

II

3

0

nd

2A

no

Lung, lower lobe

17448

2, 3

M

71

Ad-SCC

II

2

0

X

1B

no

Colon, splenic flexure

17641

1, 2, 3

F

59

Ad, NOS

II

X

X

nd

nd

FOLFIRI & Avastin, Erbitux, irinotecan then oxaliplatin & Xeloda then SAHA, 5-FU and leucovorin.

Cecum

17651

3

F

74

NE

n.d.

4

1

X

4

no

Rectosigmoid junction

18023

4

F

46

Ad, Mucinous

II

X

X

nd

nd

Avastin and FOLFOX then Xeloda and Avastin

Pancreas, overlapping lesion

18254

1, 2

F

69

Inf Duct, NOS

III

3

1

X

2B

no

Floor of mouth, NOS

18316

2

F

47

SCC, krt

I

X

X

nd

nd

Cisplatin and Taxotere

Duodenum

18484

2

M

77

Ad, NOS

II

4

1

0

3

no

Pancreas, head of

18643

2

F

56

Inf Duct, NOS

I

3

1

0

2B

Chemoradiation: total of 5040 cGy with gemcitabine

Pancreas, overlapping lesion

19632

2

F

78

Inf Duct, NOS

III

3

0

nd

2A

no

Palate, soft, NOS

19785

5

M

65

SCC, lg cell, nonkrt

III

0

0

X

nd

Induction chemotherapy

  1. For each tumor listed, the sex, age at first diagnosis, histological description, histological grade, pathological stage and treatment (if any) prior to specimen acquisition is included. The ID# refers to the de-identified number given to the procured samples. Exp indicates the experiments for which the xenograft of each tumor was used: 1- validation of antibody species-specificity, 2-localization of human mitochondria, 3- survey of time to first passage and species identification of vasculature, 4- kinetics of vascularization of engrafted tumors and 5- the perfusion study. For histological descriptions, the following abbreviations are used: NOS- not otherwise specified, Ad- adenocarcinoma, PSC- papillary serous cystadenocarcinoma, SSPC- serous surface papillary carcinoma, Meso- mesothelioma, biphasic, malignant, Inf Duct- infiltrating ductal carcinoma, RCC- renal cell carcinoma, SCC- squamous cell carcinoma, CSC- combined small cell carcinoma, Ad-Sq- adenosquamous, NE- neuroendocrine, krt- keratinizing. For histological grades the following definitions were used: Grade I: well differentiated, Grade II: moderately differentiated, moderately well differentiated, intermediate differentiated, Grade III: poorly differentiated, Grade IV: undifferentiated, anaplastic. Histological staging is per AJCC (American Joint Committee on Cancer), nd- no data.