Figure 1

Defining the effect of intrathecal tracer infusion on intracranial pressure (ICP). Ventricular ICP was monitored continuously during infusion of CSF tracer Texas Red-conjugated dextran (TR-d3, MW 3 kD) in rats. (A) Intracisternal TR-d3 infusion at 1.6 ul/min did not appreciatively alter ICP, whereas increasing the infusion rate to 3.2 and 6.4 ul/min significantly elevated ICP. (B) Intracisternal and lumbar infusion of TR-d3 did at 1.6 μl/min for 60min did not significantly alter ICP (n = 4 per group).