Table 3 Cox regression analysis of GBM patients in relation to clinicopathological factors and miRNA expression
Variables | Subset | P-Value | Hazard ratio | 95% C.I. | ||
|---|---|---|---|---|---|---|
Lower | Upper | |||||
Univariate analysis | ||||||
Age(year) | 20-34/35-64/65+ | 1.79E-13 | 2.052 | 1.695 | 2.485 | |
Gender | Male/Female | 0.801753 | 0.973 | 0.787 | 1.204 | |
Recurrence | Yes/No | 8.33E-08 | 0.530 | 0.420 | 0.668 | |
MicroRNAs | Percentile | Â | ||||
Decreased (low/high) | miR-323 | 75% | 0.00430 | 1.411 | 1.114 | 1.786 |
miR-326 | 75% | 0.03847 | 0.770 | 0.602 | 0.986 | |
miR-329 | 75% | 0.01816 | 1.331 | 1.050 | 1.688 | |
Increased (high/low) | miR-130a | 25% | 0.01028 | 1.381 | 1.079 | 1.766 |
miR-155 | 50% | 0.01909 | 0.778 | 0.631 | 0.960 | |
75% | 0.01693 | 0.744 | 0.584 | 0.948 | ||
miR-210 | 25% | 0.00676 | 0.723 | 0.571 | 0.914 | |
50% | 0.00767 | 0.753 | 0.611 | 0.928 | ||
Interactions | M323*M130a@ | 75%*25% | 7E-05 | 1.243 | 1.1165 | 1.383 |
M326*M155 | 75%*50% | 0.00432 | 0.861 | 0.778 | 0.954 | |
M326*M210 | 75%*25% | 0.00146 | 0.829 | 0.739 | 0.931 | |
M329*M130 | 75%*25% | 0.00099 | 1.196 | 1.075 | 1.331 | |
Multivariate analysis | ||||||
Age (year) | 20-34/35-64/65+ | 1.27E-08 | 1.797 | 1.469 | 2.200 | |
Recurrence | Yes/No | 9.26E-05 | 0.620 | 0.488 | 0.788 | |
miR-323 | 75% | 0.05391 | 1.267 | 0.996 | 1.611 | |
miR-326 | 75% | 0.00567 | 0.701 | 0.544 | 0.901 | |
miR-329 | 75% | 0.07446 | 1.244 | 0.979 | 1.581 | |
miR-130a | 25% | 0.00994 | 1.387 | 1.082 | 1.779 | |
miR-155 | 50% | 0.03335 | 0.796 | 0.646 | 0.982 | |
miR-210 | 25% | 0.01697 | 0.749 | 0.591 | 0.949 | |
M323*M130a | 75%*25% | 0.00142 | 1.195 | 1.071 | 1.333 | |
M326*M155 | 75%*50% | 0.00097 | 0.840 | 0.758 | 0.932 | |
M326*M210 | 75%*25% | 0.00026 | 0.806 | 0.718 | 0.905 | |
M329*M130 | 75%*25% | 0.00342 | 1.177 | 1.055 | 1.313 | |