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Table 3 Cox regression analysis of GBM patients in relation to clinicopathological factors and miRNA expression

From: Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

Variables Subset P-Value Hazard ratio 95% C.I.
Lower Upper
Univariate analysis
Age(year) 20-34/35-64/65+ 1.79E-13 2.052 1.695 2.485
Gender Male/Female 0.801753 0.973 0.787 1.204
Recurrence Yes/No 8.33E-08 0.530 0.420 0.668
MicroRNAs Percentile  
Decreased (low/high) miR-323 75% 0.00430 1.411 1.114 1.786
miR-326 75% 0.03847 0.770 0.602 0.986
miR-329 75% 0.01816 1.331 1.050 1.688
Increased (high/low) miR-130a 25% 0.01028 1.381 1.079 1.766
miR-155 50% 0.01909 0.778 0.631 0.960
75% 0.01693 0.744 0.584 0.948
miR-210 25% 0.00676 0.723 0.571 0.914
50% 0.00767 0.753 0.611 0.928
Interactions M323*M130a@ 75%*25% 7E-05 1.243 1.1165 1.383
M326*M155 75%*50% 0.00432 0.861 0.778 0.954
M326*M210 75%*25% 0.00146 0.829 0.739 0.931
M329*M130 75%*25% 0.00099 1.196 1.075 1.331
Multivariate analysis
Age (year) 20-34/35-64/65+ 1.27E-08 1.797 1.469 2.200
Recurrence Yes/No 9.26E-05 0.620 0.488 0.788
miR-323 75% 0.05391 1.267 0.996 1.611
miR-326 75% 0.00567 0.701 0.544 0.901
miR-329 75% 0.07446 1.244 0.979 1.581
miR-130a 25% 0.00994 1.387 1.082 1.779
miR-155 50% 0.03335 0.796 0.646 0.982
miR-210 25% 0.01697 0.749 0.591 0.949
M323*M130a 75%*25% 0.00142 1.195 1.071 1.333
M326*M155 75%*50% 0.00097 0.840 0.758 0.932
M326*M210 75%*25% 0.00026 0.806 0.718 0.905
M329*M130 75%*25% 0.00342 1.177 1.055 1.313
  1. @M denotes miR.