Figure 1From: PIM2 induced MMP-9 expression in macrophages requires PI3K and Notch1 signalingPIM2 induced COX-2 and MMP-9 expression and a model depicting signaling cascades regulating their expression: PIM2 treated macrophages shows upregulated COX-2 and MMP-9 expression both at mRNA and protein levels as analyzed by qRT-PCR, immunoblotting, FACS and confocal microscopy. Immunoflourescent staining of NS-398 treated macrophages shows decreased MMP-9 expression.Back to article page