Skip to main content

Table 6 Genotype and allele frequency of cytokines in periodontitis patients (CP) and control subjects

From: Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients

Genotypes

CP Patients

n = 440

(%)

Healthy subjects

n = 850

(%)

CP versus Controls

Alleles

CP patients

n = 880

(%)

Healthy subjects

n = 1700

(%)

CP versus Controls

   

OR

(95% CI)

X 2

p values

   

OR

(95% CI)

X 2

p values

IL-1α

         

*C/C

229(52)

170(20)

4.3681

23.32

C

546(62)

935(55)

1.13597

1.78

T/T

123(28)

85(10)

(2.3089-8.2638)

<0.0001

T

334(38)

765(45)

(0.865-2.1374)

0.1822

C/T

88(20)

595 (70)

       

IL-1β

         

*T/T

128(29)

314(37)

0.7132

0.97

T

510(58)

986(58)

0.9974

0

C/C

61(14)

179(21)

(0.3624-1.4035)

0.3247

C

370(42)

714(42)

(0.6393-1.5559)

1.000

C/T

251(57)

357(42)

       

IL-6

         

*G/G

110(25)

408(48)

0.3595

8.57

G

510(58)

1037(61)

0.8781

0.33

C/C/

25(8)

221(26)

0.177-0.7301

0.0034

C

370(42)

663(39)

(0.5626-1.3706)

0.5657

G/C

295(67)

221(26)

       

TNF-α

         

*G/G

189(43)

145(17)

3.7156

17.47

G

502(57)

578(34)

2.5054

17.23

A/A

132(30)

408(48)

(1.9432-7.1043)

0.0001

A

378(43)

1122(66)

(1.6056-3.9095)

0.0001

A/G

119(27)

297(35)

       

IFN-γ

         

*T/T

251(57)

476(56)

1.0382

0.010.9203

T

580(66)

1105(65)

1.0475

0.04

A/A

106(24)

221(26)

(0.5548-1.9427)

 

A

300(34)

595(35)

(0.6594-1.664)

0.8415

T/A

83(19)

153(18)

       

IL-4

         

*C/C

9(2)

230(27)

16.0032

13.2

C

211(24)

935(55)

3.8369

30.16

T/T

242(55)

153(18)

(2.1784-117.5633)

0.0003

T

669(76)

765(45)

(2.3075-6.3797)

0.0001

T/C

189(43)

467(55)

       

IL-10

         

*A/A

277(63)

782(92)

6.5546

5.211

A

590(67)

1581(93)

6.5731

63.26

G/G

132(30)

51(6)

(3.2316-13.2948)

0.0001

G

290(33)

119(7)

(3.9186-11.0259)

0.0001

A/G

31(7)

17(2)

       
  1. IL-1α: T/T+C/T versus C/C; IL-1β: C/C+ C/T versus T/T;
  2. IL-6: C/C+G/C versus G/G; TNF-α: A/A+A/G versus G/G;
  3. IFN-γ: A/A+T/A versus T/T; IL-4: T/T +T/C versus C/C;
  4. IL-10: G/G+A/G versus A/A
  5. OR, odds ratio; CI, confidence interval;
  6. Significant difference from the control, *p < 0.05