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Table 1 Peptides targeting tumor blood vessels

From: Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery

Sequence (no. of amino acids, name) Tumor types tested Receptors Applications References
CDCRGDCFC(9, RGD) Various tumor types αvβ3 and αvβ5 integrins Targeted diagnosis and therapy(TD and TT) [37, 44]
CNGRCVSGCAGRC(13, NGR)
CNGRC(5, NGR-2C)
Various tumor types CD13 TD and TT [36, 37]
CTPSPFSHC(9, TCP-1) Orthotopic colorectal cancer and gastric cancer ND* TD and TT [19]
IFLLWQR(7, IF7) Melanoma
Colorectal cancer
Anxa1 TT [60]
CTTHWGFTLC(10) MDA-MB-435-derived breast carcinomas
KS1767-derived Kaposi’s sarcomas
MMP-2
MMP-9
TT [95]
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (31, F3) HL-60 human leukemia tumor
MDA-MB-435 tumors
Nucleolin ND [35, 65]
CSRPRRSEC(9) HPV16-induced dysplastic skin    
CGKRK(5) and CDTRL(5) HPV16-induced skin carcinoma
Breast carcinomas
ND ND [58]
CKAAKNK(7, KAA) and CKGAKAR(7, KAR) Pancreatic tumors ND ND [59]
CRGRRST(7,RGR) Pancreatic tumors
Angiogenic islets
PDGF-β ND [59]
CRGDK/R GPD/E C (9, iRGD) Various tumor types αv integrins and neuropilin-1 TD and TT [63, 64]
CPRECESIC(9) EF43-fgf4-derived breast tumor
MDA-MB-435-derived breast tumor
Aminopeptidase A TT [96]
CGNSNPKSC(9, GX1) Gastric cancer ND TD and TT [97]
SVSVGMKPSPRP (12, SP5-52) Several cancers ND TT [56]
  1. *Not determined