The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer

Table 1 Detection of chromosomal regions with a high copy number (more than 6) in the gastric cancer cell lines MKN7, MKN28, and MKN74 using a genome-wide SNP microarray analysis

Chromosomal regions^a	Genes with a high copy number in the region
9p13	PAX5
17q12-q21	FBXL20, MED1, PERLD1, ERBB2, IKZF3, ZPBP2
19q12	CCNE1
19q13	CD22
22q11	DGCR8, USP41, ZNF74, SCARF2, KLHL22, MED15, PI4KA, SERPIND1, SNAP29, CRKL, THAP7, P2RX6, LOC729526

^a If more than four consecutive SNP probes with a copy number of more than six were detected in either of the three cell lines, the chromosomal region was regarded as being a “highly amplified region” and was listed in this table.

ISSN: 1479-5876