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Table 4 Univariate and multivariate Cox regression analyses of different prognostic variables for NPC patients

From: Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

Variable Subset Hazard ratio (95%) CI P value
Univariate analysis (n = 507)    
Hsp70 membranal and cytoplasmic staining low vs. high 0.540 (0.390-0.747) <0.001
Hsp70 nucleus staining low vs. high 1.708 (1.241-2.351) 0.001
Age <46 vs. > = 46 1.644 (1.202-2.249) 0.002
Sex male vs. female 0.827 (0.574-1.192) 0.308
T stage T1 + T2 vs. T3 + T4 3.149 (2.159-4.594) <0.001
N stage N0 vs. N1 + N2 + N3 2.474 (1.592-3.846) <0.001
Recurrence or metastasis No vs. Yes 548.914 (76.728-3.927E3) <0.001
Clinical stage I + II vs. III + IV 6.034 (3.352-10.862) <0.001
Multivariate analysis (n = 507)    
Hsp70 cytoplasmic and membranal staining low vs. high 0.529 (0.360-0.778) 0.001
Hsp70 nuclear staining low vs. high 2.601 (1.785-3.789) 6.41E-07
Clinical stage I + II vs. III + IV 3.641 (1.623-8.170) 0.002
  1. CI, confidence interval; WHO, World Health Organization; Hsp70, heat shock protein 70.