A retrospective pooled analysis of response patterns and risk factors in recurrent malignant glioma patients receiving a nitrosourea-based chemotherapy

Table 3 Multivariable penalized logistic regression using Firth’s correction

Response variable = Disease control (CR + PR + SD)
Effect	Odds ratio	Lower 95% Confidence Limit	Upper 95% Confidence Limit	P-Value
Gender - Female vs Male	0.906	0.452	1.800	0.7806
Second Surgery	2.802	1.152	7.334	0.0306
Time from radiotherapy	1.075	1.019	1.147	0.0161
Number of TMZ cycles	0.925	0.838	1.013	0.1053

Response variable is Disease control (CR + PR + SD). Odds ratios for time from radiotherapy and number of TMZ cycles show an improvement ratio (OR > 1) associated with an increase of 1 month in time from radiotherapy and the deterioration ratio (OR < 1) associated with an increase of 1 cycle in number of TMZ.

ISSN: 1479-5876