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Figure 3 | Journal of Translational Medicine

Figure 3

From: Functional hyper-IL-6 from vaccinia virus-colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy

Figure 3

Detection of hyper-IL-6 in tumors and blood serum samples of GLV-1h90-injected mice. Quantification (ELISA) of hyper-IL-6 in tumor lysates (A) and blood serum samples (B) of mock-, 5 × 106 pfu GLV-1h68- or GLV-1h90-injected mice at 2, 5, 9 and 14 dpi. (C) Whole tumor cross sections (100 μm) 11 days post injection of 5 × 106 pfu GLV-1h68 or GLV-1h90 were stained with anti-IL-6 antibody (red) to confirm hyper-IL-6 expression only in GLV-1h90-infected tumors. Viral infection was indicated by GFP (green), and nuclei were stained with Hoechst 33342 (blue). Scale bars indicate 5 mm.

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