Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study

Table 3 Biomolecular alterations and ORR, PFS and OS: multivariate analysis

	PFS HR (95% CI)	p	OS HR (95% CI)	p
KRAS (mutated vs wild type)	1.86 (0.99-3.47)	0.052	1.56 (0.83-2.96)	0.170
BRAF (mutated vs wild type)	2.65 (1.33-5.29)	0.006	2.47 (1.26-4.85)	0.008
PIK3CA (mutated vs wild type)	2.46 (1.10-5.52)	0.028	2.51 (1.10-5.72)	0.029
PTEN (<5% vs ≥5%)	1.47 (0.85-2.54)	0.169	0.89 (0.50-1.57)	0.686

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