Figure 8

Proposed mechanisms underlying the effects of obesity control (i.e., body weight reduction) on CLI in a murine model based on the findings of the present study. BMP-2 = bone morphogenic protein 2; Cyt-C = cytochrome C; EPC = endothelial progenitor cells; ICAM-1 = intercellular adhesion molecule 1; SDF-1α = stromal cell-derived factor-1 alpha; TGF-β = transforming growth factor beta.