Figure 3

Effect of treatment-induced regression of A375 melanoma xenografts on host survival. A375 melanoma-bearing mice were treated as in Table 1. Host survival was studied in the following treatment conditions: (○) physiologic saline; (●) G3139 + VRP + ACV; (□) G3139 + VRP + ACV + PAC.PBP + DNR; (■) G3139 + VRP + ACV + X-rays; (Δ) G3139 + VRP + ACV + PAC.PBP + DNR + X rays. Representative photos here below correspond to two control mice treated with physiological saline and two mice treated with the full combination therapy that had > 120-day survival. Data are means + S.D. for 20 different mice in each experimental condition.