Expression of TLR4 and MyD88 in normal ovarian tissue, benign cysts, borderline tumors and EOC. Detection of TLR4 and MyD88 immunoreactivity in normal ovarian tissue (a-d), benign cysts (e-h), borderline tumors (i-l), and EOC (m-p). Original magnification, (a, c, e, g, i, k, m, o) × 200; (b, d, f, h, j, l, n, p) × 400. Normal ovarian tissue showed no or weak immunoreactions for TLR4 (a, b). Strong immunostaining of TLR4, which was localized in the membrane or cytoplasm, was observed in the benign cysts (e, f), borderline tumors (i, j) and EOC (m, n). In contrast to the situation in the normal ovarian tissue (c, d), benign cysts (g, h), borderline tumors (k, l), strong immunostaining of MyD88, which was localized in the cytoplasm, was vserved in EOC (o, p).