Skip to main content

Table 7 Percentage change of lipids according to SLCO1B1 haplotypes after 12 months of raloxifene treatment in 53 postmenopausal women

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

  Haplotype
  *1b *15 *1a
Number of copies of haplotype 0 1 2 p value (ANOVA) 0 1 p value (t-test) 0 1 2 p value (ANOVA)
Δ HOL (%) −0.8 (2.9) −4.8 (2.2) −10.2 (3.0) 0.228 −3.9 (1.8) −2.8 (3.7) 0.747 −6.9 (2.0) −3.8 (2.7) 0.3 (2.6) 0.363
Δ HDL (%) −0.7 (2.9) 3.8 (3.2) −9.7 (5.3) 0.149 0.5 (2.4) 0.3 (4.0) 0.963 −3.9 (4.0) 2.7 (3.1) −1.0 (3.0) 0.416
Δ LDL (%) −0.05 (4.01) −7.8 (2.7) −13.0 (5.8) 0.140 −4.8 (2.5) −5.2 (5.0) 0.935 −10.3 (3.4) −5.9 (3.4) 3.0 (4.1) 0.140
Δ TG (%) 8.7 (7.7) −1.0 (6.4) 7.8 (20.7) 0.626 −0.7 (6.0) 14.5 (7.7) 0.145 21.3 (12.1) −5.9 (4.2) 12.7 (14.0) 0.051