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Table 6 Percentage change of lipids according to SLCO1B1 c.388A > G, SLCO1B1 c.521T > C and SLCO1B3 int7A > G genotypes after 12 months of raloxifene treatment in 53 postmenopausal women

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

  Genotype
SLCO1B1 c.388A > G SLCO1B1 c.521T > C SLCO1B3 int7 T → G
AA AG GG p value (ANOVA) TT TC p value (t-test) CC non CC p value (t-test)
Δ HOL (%) 0.08 (±2.41) −3.8 (±2.8) −6.9 (±2.0) 0.368 −4.0 (±1.9) −2.7 (±3.5) 0.725 −2.3 (±2.1) −6.1 (±2.7) 0.291
Δ HDL (%) −1.3 (±2.7) 3.0 (±3.2) −3.9 (±4.0) 0.379 0.7 (±2.5) 0.06 (±3.7) 0.890 1.7 (±2.4) −2.0 (±3.8) 0.393
Δ LDL (%) 2.7 (±3.8) −6.1 (±3.5) −10.3 (±3.4) 0.132 −4.9 (±2.5) −4.9 (±4.7) 0.994 −4.4 (±3.1) −5.8 (±3.2) 0.781
Δ TG (%) 12.9 (±12.8) −6.7 (±4.2) 21.3 (±12.1) 0.041 a −1.2 (±6.8) 14.6 (±7.2) 0.124 6.8 (±6.4) −0.9 (±7.1) 0.455
  1. The values are presented as means (standard errors).
  2. aBonferoni test (ANOVA), no differences.