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Table 3 Summary of concentrations of raloxifene species by SLCO1B1 and SLCO1B3 polymorphisms

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

  Genotype
SLCO1B1 c.388A > G SLCO1B1 c.521T > C SLCO1B3 int7C > G
AA AG GG p value (ANOVA) TT TC p value (t-test) CC non-CC p value (t-test)
c (M1) (nmol/l) 60 (19) 63 (12) 99 (19) 0.143 65 (11) 79 (15) 0.400 68 (10) 75 (19) 0.830
c (M2) (nmol/l) 268 (90) 288 (53) 439 (101) 0.225 254 (43) 431 (85) 0.076 313 (51) 321 (77) 0.959
c (M3) (nmol/l) 266 (88) 395 (73) 1073 (305) 0.001 a 545 (130) 446 (98) 0.917 411 (53) 715 (246) 0.339
c (RAL) (nmol/l) 1.9 (0.5) 3.5 (0.5) 5.6 (0.9) 0.004 b 3.5 (0.6) 3.8 (0.5) 0.308 3.2 (0.4) 4.5 (0.8) 0.166
c (TR) (nmol/l) 596 (182) 750 (130) 1617 (381) 0.009 c 867 (174) 960 (167) 0.519 795 (107) 1115 (321) 0.428
  1. The values of concentrations are presented as means (standard errors).
  2. aBonferoni post hoc test (ANOVA), p = 0.004 for AG vs. GG,p =0.001 for AA vs. GG.
  3. bBonferoni post hoc test (ANOVA), p = 0.003 for AA vs. GG.
  4. cBonferoni post hoc test (ANOVA), p = 0.014 for AA vs. GG,p =0.020 for AG vs. GG.
  5. M1, raloxifene-6-β-glucuronide; M2, raloxifene-4'- β –glucuronide; M3, raloxifene-6,4'- di –glucuronide; RAL, raloxifene; TR, total raloxifene.