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Table 3 Summary of concentrations of raloxifene species by SLCO1B1 and SLCO1B3 polymorphisms

From: Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

 

Genotype

SLCO1B1 c.388A > G

SLCO1B1 c.521T > C

SLCO1B3 int7C > G

AA

AG

GG

p value (ANOVA)

TT

TC

p value (t-test)

CC

non-CC

p value (t-test)

c (M1) (nmol/l)

60 (19)

63 (12)

99 (19)

0.143

65 (11)

79 (15)

0.400

68 (10)

75 (19)

0.830

c (M2) (nmol/l)

268 (90)

288 (53)

439 (101)

0.225

254 (43)

431 (85)

0.076

313 (51)

321 (77)

0.959

c (M3) (nmol/l)

266 (88)

395 (73)

1073 (305)

0.001 a

545 (130)

446 (98)

0.917

411 (53)

715 (246)

0.339

c (RAL) (nmol/l)

1.9 (0.5)

3.5 (0.5)

5.6 (0.9)

0.004 b

3.5 (0.6)

3.8 (0.5)

0.308

3.2 (0.4)

4.5 (0.8)

0.166

c (TR) (nmol/l)

596 (182)

750 (130)

1617 (381)

0.009 c

867 (174)

960 (167)

0.519

795 (107)

1115 (321)

0.428

  1. The values of concentrations are presented as means (standard errors).
  2. aBonferoni post hoc test (ANOVA), p = 0.004 for AG vs. GG,p =0.001 for AA vs. GG.
  3. bBonferoni post hoc test (ANOVA), p = 0.003 for AA vs. GG.
  4. cBonferoni post hoc test (ANOVA), p = 0.014 for AA vs. GG,p =0.020 for AG vs. GG.
  5. M1, raloxifene-6-β-glucuronide; M2, raloxifene-4'- β –glucuronide; M3, raloxifene-6,4'- di –glucuronide; RAL, raloxifene; TR, total raloxifene.
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Journal of Translational Medicine

ISSN: 1479-5876

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