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Figure 6 | Journal of Translational Medicine

Figure 6

From: The Stanford Data Miner: a novel approach for integrating and exploring heterogeneous immunological data

Figure 6

OLAP integration of data from disparate types of assays and multiple projects, with demographic metadata. (A) Serum IL-6 as measured by MSD assay is compared to CD4+ pSTAT1 expression as measured by phosphoepitope flow cytometry (baseline and IL-6-stimulated pSTAT1 MFI, as well as fold-change (stim/unstim) are all shown). Data for three healthy cohorts (Projects) are displayed in columns, broken out by gender. (B) Graphing the mean serum IL-6 levels as a function of mean CD4+ pSTAT1 IL-6 stim/unstim ratios for males and females in each study shows higher serum IL-6 means in females, and correspondingly lower pSTAT1 induction in response to IL-6 stimulation in CD4+ T cells. A possible hypothesis is that chronically high IL-6 levels in females result in poorer pSTAT1 induction in response to IL-6.

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