Figure 5

(A) Assay group by Sample Day. This OLAP cube displays aggregated data from each of three different assay types, and groups them by time point (day 0, 7, and 28). It is immediately apparent which assays were performed at which time points. (B) Identification of cytokines with gender bias. Expanding the Analytes dimension, and diplaying Gender in columns, we have selected those cytokines (4 of 51 analyzed) that show > 20% difference in mean expression between males and females. By also displaying Lot # in rows, we can see that the trends are preserved across two different lots of Luminex kits (H51-1 and H51-2), although absolute values vary by lot. For GM-CSF, the trend is also seen in a different type of assay (MSD 9-plex, shown as lot H9-2, 4/10). Other cytokines were not run in this assay type, so the cross-platform comparison can only be made for GM-CSF. Gender biases of the type shown here have been previously reported for ENA-78 [9], leptin [10, 11], and PDGF [12], but to our knowledge not for GM-CSF. "Mean" indicates the mean MFI (median fluorescence intensity) of the indicated number of samples (N). Graphs of the data are exported from the native application to demonstrate the graphing functions of SDM.