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Table 3 In vitro relaxation of phenylephrine-pre-contracted corpora cavernosa from normal (control) or diabetic rabbits by SAR407899 and sildenafil: effect of the NO synthase inhibitor L-NAME (0.3 mM)

From: Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa

  RELAXATION OF RABBIT CORPUS CAVERNOSUM IC50, μM (95% confidence interval) %Emax ± SEM
  Controls Diabetes
  --- L-NAME --- L-NAME
SAR407899 0.40 0.28 ** 0.42 ## 0.42
  (0.23-0.69) (0.13-0.60) (0.20-0.90) (0.14-1.26)
  95 ± 1.4§ 93 ± 2.3*** 95 ± 1.4### 96 ± 1.4
SILDENAFIL 0.22 1.13 1.45 1.47
  (0.11-0.45) (0.35-3.66) (0.27-7.81) (1.01-2.14)
  83 ± 2.3 65 ± 9.9 65 ± 9.6 45 ± 5.3
  1. Maximal effect is expressed as a percentage of the relaxation induced by 0.1 mM papaverine. Results were analyzed by three-way ANOVA + Winer analysis. Significance of differences between groups: § p < 0.05 vs. sildenafil control (-L-NAME); ** 0.001 < p < 0.01 vs. sildenafil control (+L-NAME); ***p < 0.001 vs. sildenafil control (+L-NAME); ## 0.001 < p < 0.01 vs. sildenafil control (-L-NAME); ### p < 0.001 vs. sildenafil control (-L-NAME); 0.001 < p < 0.01 vs. sildenafil diabetic (+L-NAME); p < 0.001 vs. sildenafil diabetic (+L-NAME)