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Table 2 In vitro relaxation of phenylephrine-pre-contracted strips from normotensive WKY or genetically hypertensive (SHR) rats by SAR407899, sildenafil and Y 27632: effect of the NO synthase inhibitor L-NAME (0.3 mM)

From: Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa

  RELAXATION OF RAT CORPUS CAVERNOSUM IC50, μM (95% confidence interval) %Emax ± SEM
  WKY SHR
  --- L-NAME --- L-NAME
SAR407899 0.10 (0.009-1.270) 89 ± 3.5 0.13 (0.021-0.901) 86 ± 2.4 0.29 (0.189-0.460) 94 ± 1.3 0.28 (0.213-0.384) 94 ± 1.2
SILDENAFIL 0.02 0.18 ** 0.08 0.34 **
  (0.014-0.060) (0.048-0.716) (0.039-0.155) (0.146-0.814)
  91 ± 3.4 77 ± 5.7 82 ± 3.0 65 ± 3.6
Y 27632 0.09 0.61 0.19 0.56
  (0.030-0.299) (0.373-1.025) (0.031-1.147) (0.272-1.185)
  92 ± 3.2 89 ± 3.7 92 ± 2.5 87 ± 2.3
  1. Maximal effect is expressed as a percentage of the relaxation induced by 0.1 mM papaverine. Results were analyzed by one-way ANOVA + Newman-Keuls test. Significance of differences between groups: ** p < 0.003 vs. without L-NAME