Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy

Lee, Young-Ho; Choi, Kyung Vin; Moon, Jin Hwa; Jun, Hyun-Joo; Kang, Hye-Ryeong; Oh, Se-In; Kim, Hyung Sun; Um, Jang Soo; Kim, Mi Jung; Choi, Yun Young; Lee, Young-Jun; Kim, Hee-Jin; Lee, Jong-Hwa; Son, Su Min; Choi, Soo-Jin; Oh, Wonil; Yang, Yoon-Sun

doi:10.1186/1479-5876-10-58

Table 2 Differences of white matter integrity (FA values) of the 5 patients who showed neurodevelopmental improvement

From: Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy

ROIs		UPN 8		UPN 9		UPN 11		UPN 12		UPN 13
		Pre	Post	Pre	Post	Pre	Post	Pre	Post	Pre	Post
Temporal	TR *	0.431	0.451	0.438	0.421	0.425	0.445	0.463	0.464	0.416	0.430
	TL	0.483	0.457	0.448	0.456	0.319	0.346	0.460	0.444	0.423	0.460
Orbito-frontal	FR	0.411	0.465	0.470	0.378	0.359	0.386	0.421	0.438	0.466	0.728
	FL	0.469	0.490	0.450	0.383	0.319	0.336	0.423	0.438	0.462	0.450
Inferior frontal	IFR	0.453	0.446	0.444	0.447	0.397	0.370	0.404	0.437	0.443	0.474
	IFL	0.506	0.515	0.494	0.383	0.320	0.334	0.457	0.464	0.452	0.454
Internal capsule	ICR	0.489	0.499	0.498	0.570	0.501	0.534	0.476	0.498	0.467	0.465
	ICL	0.527	0.520	0.493	0.504	0.336	0.328	0.496	0.496	0.478	0.454
	CC *	0.534	0.538	0.493	0.487	0.421	0.427	0.443	0.509	0.481	0.447
	S	0.502	0.536	0.472	0.495	0.421	0.421	0.512	0.549	0.471	0.465
Periventricular white matter	AWMR	0.374	0.366	0.363	0.300	0.363	0.369	0.363	0.307	0.373	0.332
	AWML	0.423	0.385	0.375	0.315	0.264	0.228	0.349	0.371	0.332	0.378
	PWMR*	0.479	0.479	0.400	0.425	0.426	0.481	0.407	0.415	0.398	0.408
	PWML	0.488	0.484	0.476	0.442	0.314	0.392	0.459	0.444	0.414	0.410
Occipital	OR	0.443	0.457	0.523	0.449	0.441	0.446	0.450	0.430	0.414	0.434
	OL	0.483	0.510	0.488	0.395	0.284	0.271	0.536	0.509	0.441	0.391
Sup frontal subcortex	SFR	0.475	0.447	0.484	0.444	0.346	0.330	0.345	0.431	0.452	0.433
	SFL	0.455	0.460	0.443	0.360	0.308	0.334	0.399	0.401	0.452	0.440
Middle frontal paravent WM	MFPAR	0.336	0.319	0.363	0.379	0.389	0.396	0.378	0.381	0.389	0.414
	MFPAL	0.455	0.447	0.433	0.389	0.263	0.237	0.385	0.387	0.387	0.438
Parietal perivent WM	PPER	0.468	0.451	0.447	0.440	0.466	0.504	0.446	0.479	0.435	0.445
	PPEL	0.519	0.514	0.458	0.456	0.342	0.350	0.453	0.458	0.446	0.453
Post parietal perivent WM	PPPER	0.467	0.507	0.405	0.467	0.477	0.495	0.492	0.488	0.391	0.476
	PPPEL	0.465	0.466	0.464	0.427	0.284	0.284	0.452	0.525	0.408	0.372
Post parietal paravent WM	PPPAR	0.445	0.497	0.336	0.412	0.480	0.477	0.433	0.473	0.425	0.508
	PPPAL	0.441	0.443	0.381	0.359	0.273	0.288	0.448	0.422	0.374	0.425

UPN; unique patient number, TR; right temporal, TL; left temporal, FR; right orbito-frontal, FL; left orbito-frontal, IFR; right inferior frontal, IFL; left inferior frontal, ICR; right internal capsule, ICL; left internal capsule, CC; corpus callosum, S; splenium, AWMR; right anterior periventricular white matter, AWML; left anterior periventricular white matter, PWMR; right posterior periventricular white matter, PWML; left posterior periventricular white matter, OR; right occipital, OL; left occipital, SFR; right superior frontal subcortex, SFL; left superior frontal subcortex, MFPAR; right anterior middle frontal paraventricular white matter, MFPAL; left anterior middle frontal paraventricular white matter, PPER; right parietal periventricular white matter, PPEL; left parietal periventricular white matter, PPPER; right posterior parietal periventricular white matter, PPPEL; left posterior parietal periventricular white matter, PPPAR; right posterior parietal paraventricular white matter, PPPAL; left posterior parietal paraventricular white matter (* indicates the ROIs demonstrated significant differences between pre-treatment and post-treatment values out of 26 ROIs.)

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ISSN: 1479-5876

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