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Table 4 Power and sample sizes to detect single nucleotide polymorphism influencing BP response measured by office, home, ambulatory daytime and nighttime blood pressure

From: Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response

  Drug
  Atenolol Hydrochlorothiazide
  Power, N = 300 N, 80% power Power, N = 300 N, 80% power
Systolic BP response signal 80% 300 80% 300
   Measurement methods     
Office 4% 780 1.5% 1013
Home 42% 416 24% 500
Ambulatory day 41% 420 18% 540
Ambulatory night 17% 552 12% 607
   Weighted averages     
All methods 70% 328 61% 353
Home and office 45% 404 30% 467
Diastolic BP response signal 80% 300 80% 300
   Measurement methods     
Office 5% 764 3% 884
Home 39% 426 19% 537
Ambulatory day 39% 426 19% 537
Ambulatory night 27% 484 7% 695
   Weighted averages     
All methods 63% 348   379
Home and office 42% 416 26% 489
  1. BP, blood pressure. The power and sample size estimates are for a single nucleotide polymorphism with minor allele frequency of 0.2 that influences the BP response signal with an effect size detected with 80% power in a sample of N = 300 at a genome-wide significance level of 5 × 10-8(see Methods). The estimates assume that the BP response signal can be measured without error.