Table 2 Circulating miRNAs associated with histopathological features of BC*

hsa-miR-375

3, 189

18, 356

-2.23

6.28E-10

3.46E-07

hsa-miR-429

58

221

-1.94

7.48E-08

1.28E-05

hsa-miR-196a

184

694

-1.92

8.14E-08

1.28E-05

hsa-miR-141*

21

75

-1.82

5.99E-07

6.59E-05

hsa-miR-376a

200

65

1.63

4.72E-06

4.33E-04

hsa-miR-370

585

198

1.56

9.98E-06

8.44E-04

hsa-miR-141

442

1, 216

-1.46

3.34E-05

2.45E-03

hsa-miR-200b

150

400

-1.42

5.82E-05

3.37E-03

hsa-miR-125a-5p

2, 222

914

-1.28

2.55E-04

1.17E-02

hsa-miR-205

83

196

-1.24

4.43E-04

1.87E-02

hsa-miR-200a

218

482

-1.14

1.11E-03

4.08E-02

hsa-miR-224

870

402

1.12

1.39E-03

4.79E-02

PR+ vs. PR-

Gene name

PR⁺ (N = 14) Ave. counts

PR- (N = 28) Ave. counts

Log2 fold diff. (PR⁺ vs. PR-)

P value

FDR

hsa-miR-216a

56

17

1.75

1.20E-06

1.56E-04

hsa-miR-184

28

115

-2.03

1.28E-06

1.56E-04

hsa-miR-196a

160

578

-1.85

5.80E-06

5.28E-04

hsa-miR-370

699

238

1.55

6.24E-06

5.28E-04

hsa-miR-375

4, 457

14, 477

-1.70

2.55E-05

1.76E-03

hsa-miR-376a*

225

86

1.40

5.27E-05

3.22E-03

hsa-miR-133a

84

32

1.36

8.72E-05

4.57E-03

hsa-miR-654-5p

154

64

1.25

2.88E-04

1.29E-02

hsa-miR-125a-5p

2, 550

1077

1.24

2.93E-04

1.29E-02

hsa-miR-224

1, 028

440

1.22

3.72E-04

1.52E-02

hsa-miR-217

120

52

1.22

4.97E-04

1.89E-02

hsa-miR-429

67

176

-1.38

5.72E-04

2.10E-02

hsa-miR-494

255

114

1.16

7.86E-04

2.62E-02

hsa-miR-99b

10, 464

4934

1.08

1.56E-03

4.40E-02

HER2+ vs. HER2-

Gene name

HER2+ (N = 23) Ave. counts

HER2+ (N = 19) Ave. counts

Log2 fold diff. (HER2+. vs. HER-)

P value

FDR

hsa-miR-885-3p

32

160

-2.31

2.05E-10

1.13E-07

hsa-miR-122

98, 310

464, 256

-2.24

3.08E-10

1.13E-07

hsa-miR-375

17, 052

3, 977

2.10

1.72E-08

4.74E-06

hsa-miR-184

128

35

1.88

5.72E-07

1.05E-04

hsa-miR-1228*

65

166

-1.35

1.32E-04

7.62E-03

hsa-miR-483-5p

194

484

-1.32

1.60E-04

8.80E-03

hsa-miR-429

193

75

1.37

1.81E-04

9.48E-03

hsa-miR-205

189

80

1.23

7.03E-04

3.14E-02

hsa-miR-217

49

106

-1.12

1.41E-03

5.00E-02

Inflammatory vs. Non-inflammatory

Gene name

Inflam. (N = 10) Ave. counts

Non-inflam. (N = 32) Ave. counts

Log2 fold diff. (Inflam. vs. Non inflam.)

P value

FDR

hsa-miR-375

35, 465

3, 535

3.33

3.76E-20

4.14E-17

hsa-miR-184

267

29

3.18

5.28E-18

2.90E-15

hsa-miR-196a

1217

195

2.64

3.62E-13

1.33E-10

hsa-miR-429

341

77

2.15

4.14E-09

5.69E-07

hsa-miR-200a

811

206

1.98

6.26E-08

7.65E-06

hsa-miR-200c

3, 714

1, 033

1.85

4.22E-07

4.65E-05

hsa-miR-3065-5p

86

29

1.56

3.11E-05

3.45E-04

hsa-miR-141

1, 571

597

1.40

1.44E-04

7.19E-03

hsa-miR-203

403

155

1.38

1.93E-04

8.85E-03

hsa-miR-200b*

89

36

1.33

3.90E-04

1.59E-02

hsa-miR-1308

5, 332

2, 358

1.18

1.35E-03

4.96E-02