Figure 4

Effect of surgery and chemotherapy on ALC and ANC and relationship to clinical outcome. Friedman test followed by Dunn's post test was used to analyze (A) ALC and (B) ANC values collected prior to diagnosis (PreDx), prior to surgical treatment (PreTx), immediately prior to chemotherapy (PreChem) and immediately prior to the 4th cycle of chemotherapy (MidChem). For ALC, only the change from the pre-diagnostic time point to pre-treatment was significant. For ANC, the only insignificant change was from the pre-treatment to pre-chemotherapy time points. (C) ALC values recorded at the mid point of chemotherapy are associated with prolonged PFS by Kaplan-Meier analysis. (D) Extent of ALC recovery at the mid-point of chemotherapy (relative to pre-diagnostic ALC) is not associated with PFS in suboptimally debulked patients by Kaplan-Meier analysis.