Figure 4

Comparison of two haplotype groups from the T1DGC. A: Congruence was calculated separately for two haplotype groups, DRB1*03-B*08 and DRB1*0401-B*08 (DQB1*0302). There is a significant difference in the congruence between the two groups centromeric of HLA-B, while the congruence within the two groups is not significantly different telomeric of HLA-B. B: In these two images, each column illustrates one founder chromosome (represented by 1,818 SNPs across 2.64 Mb ranging from HLA-DRB1 to HLA-A on chromosome 6) with the specified HLA alleles (e.g., DRB1*03 and B*08). Each row illustrates data for one SNP. Yellow represents alleles that match the consensus sequence, whereas blue represents alleles that do not match the consensus. White denotes missing or unphased alleles. Congruent chromosomes are indicated by a tick mark at the bottom of the image. The DRB1*03-B*08 chromosomes are highly congruent across the entire region from HLA-DRB1 to HLA-B, and in many cases from HLA-DRB1 to HLA-A. On the other hand, the DRB1*04-B*08 (DQB1*0302) chromosomes are congruent around HLA-B but are not congruent near HLA-DRB1 or HLA-A