Figure 2
From: Phase I clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion
HER2-ICD specific antibody response. Serum from patients receiving dHER2-ASCI + lapatinib was analyzed for HER2-ICD specific antibodies by ELISA. Plates were coated with HER2-ICD protein and incubated with serial dilutions of patient sera (1:25-1:6400), along with negative control serum. Individual graphs of the HER2-ICD titer over time are presented for each patient (indicated by study number) with arrows indicating final dHER2ASCI injection.