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Table 2 Association of bacterial phyla and selected genera with urine estrogen levels in men and postmenopausal women*

From: Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study

Phyla, selected genera (mean relative abundance)

Totalestrogens†

Estrone†

Estradiol†

Estriol†

 

Beta†

P-value

Beta†

P-value

Beta†

P-value

Beta†

P-value

Firmicutes (80.3%)

0.07

0.20

0.02

0.70

-0.0001

1.00

0.05

0.30

Firmicutes Clostridia

        

non-Clostridiales (0.2%)

0.70

0.004

0.61

0.01

0.55

0.004

0.49

0.02

Firmicutes Clostridia Clostridiales

        

Ruminococcaceae Oscillibacter (1.2%)

0.67

0.01

0.62

0.01

0.32

0.15

0.36

0.13

Ruminococcaceae Subdoligranulum (2.8%)

0.59

0.03

0.47

0.04

0.19

0.40

0.46

0.04

Ruminococcaceae genus NA (4.4%)

0.57

0.002

0.45

0.01

0.17

0.29

0.44

0.01

Bacteroidetes (16.9%)

-0.07

0.19

-0.02

0.67

-0.01

0.88

-0.05

0.28

Actinobacteria (1.3%)

0.0004

0.41

-0.0003

0.93

0.001

0.72

0.005

0.21

Proteobacteria (0.5%)

-0.24

0.27

-0.29

0.13

-0.28

0.10

-0.20

0.28

Fusobacteria (0.2%)

-0.19

0.30

-0.15

0.34

-0.06

0.70

-0.22

0.15

Unclassified bacteria (0.8%)

0.39

0.11

0.33

0.12

0.21

0.29

0.28

0.18

  1. * 25 men, 7 postmenopausal women. †Level (pM/mg creatinine) in urine. †Beta values estimate the increase in loge of estrogen per loge copy for phyla, else per level (none, low, high) for genera and unclassified bacteria. P-values were not adjusted for multiple comparisons.