Table 1 Correlation of microbial β-glucuronidase, β-glucosidase, alpha diversity, and richness with urinary estrogens and estrogen metabolites
Men | Postmenopausal women | Premenopausal women | |||||
|---|---|---|---|---|---|---|---|
Estrogen and estrogen metabolites (EM)* | N=25 | N=7 | N=19 | ||||
Total estrogens, mean (SE) | 82.6 (7.6) | 68.7 (9.4) | 155.1 (34.7) | ||||
- | β-glucuronidase correlation | R=0.30 | P= 0.15 | R=0.31 | P= 0.51 | R=0.003 | P= 0.99 |
- | β-glucosidase correlation | R=0.13 | P= 0.52 | R=-0.002 | P= 1.00 | R=0.08 | P= 0.76 |
- | Shannon index | R=0.53 | P=0.007 | R=0.71 | P=0.07 | R=0.04 | P=0.89 |
- | Observed species | R=0.59 | P=0.002 | R=0.79 | P=0.04 | R=0.12 | P=0.63 |
Estrone, mean (SE) | 15.4 (2.0) | 12.1 (1.6) | 39.9 (13.8) | ||||
- | β-glucuronidase correlation | R=0.45 | P= 0.03 | R=0.27 | P= 0.56 | R=0.03 | P= 0.89 |
- | β-glucosidase correlation | R=0.32 | P= 0.12 | R=-0.13 | P= 0.79 | R=0.06 | P= 0.81 |
- | Shannon index | R=0.35 | P= 0.08 | R=0.74 | P= 0.06 | R=0.005 | P= 0.98 |
- | Observed species | R=0.45 | P=0.02 | R=0.80 | P=0.03 | R=0.09 | P=0.71 |
Estradiol, mean (SE) | 3.8 (0.5) | 1.7 (0.2) | 8.4 (2.6) | ||||
- | β-glucuronidase correlation | R=0.35 | P= 0.08 | R=0.72 | P= 0.07 | R=-0.06 | P= 0.81 |
- | β-glucosidase correlation | R=0.29 | P= 0.17 | R=0.46 | P= 0.30 | R=-0.07 | P= 0.79 |
- | Shannon index | R=0.25 | P= 0.22 | R=0.60 | P= 0.16 | R=-0.01 | P= 0.96 |
- | Observed species | R=0.38 | P=0.06 | R=0.72 | P=0.07 | R=0.09 | P=0.73 |
2-pathway EM, mean (SE) | 22.2 (2.1) | 17.9 (2.9) | 38.6 (7.7) | ||||
- | β-glucuronidase correlation | R=0.17 | P= 0.42 | R=0.13 | P= 0.79 | R=0.008 | P= 0.98 |
- | β-glucosidase correlation | R=0.14 | P= 0.51 | R=-0.11 | P= 0.82 | R=0.07 | P= 0.78 |
- | Shannon index | R=0.58 | P=0.004 | R=0.47 | P=0.29 | R=0.01 | P=0.96 |
- | Observed species | R=0.64 | P=0.0005 | R=0.60 | P=0.15 | R=0.10 | P=0.68 |
4-pathway EM, mean (SE) | 3.3 (0.3) | 3.5 (0.6) | 6.0 (1.3) | ||||
- | β-glucuronidase correlation | R=0.06 | P= 0.76 | R=0.03 | P= 0.96 | R=-0.15 | P= 0.54 |
- | β-glucosidase correlation | R=-0.03 | P= 0.87 | R=-0.22 | P= 0.63 | R=0.02 | P= 0.94 |
- | Shannon index | R=0.46 | P=0.02 | R=0.26 | P=0.57 | R=-0.04 | P=0.89 |
- | Observed species | R=0.59 | P=0.002 | R=0.49 | P=0.26 | R=0.07 | P=0.78 |
16-pathway EM, mean (SE) | 37.9 (4.4) | 33.5 (4.8) | 62.1 (12.3) | ||||
- | β-glucuronidase correlation | R=0.22 | P= 0.30 | R=0.41 | P= 0.36 | R=-0.04 | P= 0.89 |
- | β-glucosidase correlation | R=0.02 | P= 0.92 | R=0.10 | P= 0.84 | R=0.11 | P= 0.65 |
- | Shannon index | R=0.43 | P=0.04 | R=0.82 | P=0.03 | R=0.06 | P=0.82 |
- | Observed species | R=0.46 | P=0.02 | R=0.84 | P=0.02 | R=0.13 | P=0.60 |