Table 2 Genes differentially up- or downregulated in SVR in IL28B CC and IL28T* cohorts over the course of the treatment period (P < 0.05).
| Alelle | Day 0 | Day 1 | Day 7 | Day 28 | Day 56 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Up | Down | Up | Down | Up | Down | Up | Down | Up | Down | |
| IL28B CC | None | ATP6V0B | BST2 | |||||||
|
IL1B IRF2 NFKB2 PRDM1 SOCS1 |
CCL4 IFITM1 SSBP1 |
LIPA PRKRA |
ADAR ATP6V0B BTG1 CCL3 CCL4 CREB1 ICAM1 IKBKG IRF1 LYN PLAUR PRKRIR RNASEL SOCS1 STAT3 STAT6 TAP2 |
FYN IRF3 |
EIF2AK2 FAS GBP1 GTPBP2 IFI35 IFI44 IFI44L IFIT1 IFIT2 IFIT5 IFITM3 IRF7 SELL SP110 TAP2 TRIM34 |
DHX9 FYN IRF3 LIPA | IFITM3 |
CD81 FYN IKBKB IRF3 MX1 PSME2 TRIM14 TRIM26 TRIM34 | ||
| IL28B T* |
AIM2 IKBKE IRF2 LCK SOCS1 | STAT6 |
IRF2 LCK TRAF6 |
NMI YARS |
BTG1 CREB1 FAS GMPR HIF1A IFNAR1 IRF2 SELL SOCS1 TAP1 TGFB1 TRADD TRAF6 |
IL10 SHFM1 YARS | IFNAR1 |
NMI PRKRA | CREB1 |
CTLA4 IFI30 IRF5 |