Figure 2From: Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)Analysis of phospho-ERK and phospho-Akt in tumor biopsies pre-treatment compared to on-therapy. Excisional biopsy material obtained prior to therapy with R115777 and during week 7 of therapy was analyzed by Western blot for the presence of phospho-Akt, phospho-Erk, and total β-Actin.Back to article page