Figure 2
Expression profile of RTKs and the effect of dovitinib on RTK signaling in HCC and endothelial cells. A) Expression of PDGFR-β, FGFR-1, and VEGFR-2 in HCC and endothelial cell lines as detected by immunoblotting. B) Expression of FGFR-3, and VEGFR-1 in HCC and endothelial cell lines C) Phosphorylation of p-PDGFR-β and p-ERK were inhibited by dovitinib at pharmacologically relevant concentrations in MHCC-97H and SMMC7721 cells. D) Dovitinib inhibited the phosphorylation of FGFG-1, VEGFR-2, and downstream ERK in HMVEC and HUVEC endothelial cells at pharmacologically relevant concentrations.