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Table 4 Results of univariate and multivariate Cox proportional-hazards analysis for disease-specific survival

From: Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis

Variable

Subvariable

All cases (n = 221)

  

HR

95% CI

P-value

Univariate

    

Age

≥47a yr (n = 103) vs. <47 yr (n = 117)

1.654

0.931-2.938

0.086

Histology grade

I (n = 47) vs. IIIII (n = 174)

7.696

1.871-31.651

0.005*

Clinical stage

I II (n = 181) vs. III (n = 40)

4.059

2.318-7.016

<0.001*

Tumor size stage

T1 (n = 63) vs. T2 + T3 (n = 158)

2.799

1.260-6.219

0.011*

Lymph nodes metastasis

absent (n = 105) vs. present (n = 116)

3.361

1.759-6.422

<0.001*

Menopausal status

absent (n = 131) vs. present (n = 90)

1.549

0.857-2.798

0.147

Rab27B expression

low (n = 107) vs. high (n = 114)

8.661

3.897-19.251

<0.001*

ER status

absent (==97) vs. present (n = 124)

0.588

0.339-1.022

0.06

PR status

absent (n = 91) vs. present (n = 130)

0.505

0.291-0.878

0.015*

CerbB2 status

0, 1+, 2+ (n = 147) vs. 3+ (n = 74)

1.504

0.861-2.628

0.152

Multivariate

  

Histology grade

I (n = 47) vs. IIIII (n = 174)

4.808

1.154-20.030

0.031*

Tumour size

T1 (n = 63) vs. T2 + T3 (n = 158)

2.630

1.167-5.924

0.020*

Lynph nodes metastasis

absent (n = 105) vs. present (n = 116)

2.696

1.398-5.197

0.003*

Rab27B expression

low (n = 107) vs. high (n = 114)

9.120

4.056-20.506

<0.001*

PR status

absent (n = 91) vs. present (n = 130)

0.412

0.233-0.729

0.002*

  1. a Mean age. Cox propotional hazard regression model, enter; HR, Hazard ratio; CI, confidence interval; *Statistically significant difference.