miRNA | Tissue / cell lines | miRNA functions | Target gene/Pathway | Reference |
---|---|---|---|---|
miR-103/107 | obese mice: ob/ob mice and diet-induced-obese (DIO) C57BL/6J mice | regulate insulin sensitivity | caveolin-1 | 41 |
miR-122 | primary mouse hepatocytes and AML12 | regulator of cholesterol and fatty-acid metabolism | Â | 23,26,38,49,5054,60 |
miR-133 | 293FT cells | decreased GLUT4 expression and reduced insulin-mediated glucose uptake in cardio myocytes | Â | 31,34 |
miR-14 | Drosophila | regulate fat metabolism | Â | 36 |
miR-143 | liver of obese mouse models | impairs insulin-stimulated AKT activation and glucose homeostasis | Orp8 / Akt pathway | 12,26,35,36, 37,91 |
miR-146 | diabetic db/db mice islets / MIN6B1 cells | cell death | Irak1 & Traf6 / AP-1 pathway | 52 |
miR-15a/16-1 | leukemic cell line model (MEG-01) and in primary CLL samples | directly or indirectly affect apoptosis and cell cycle | MCL1, BCL2, ETS1,or JUN | 27 |
miR-195-5p | bladder cancer T24 cells | inhibited cell growth and promoted cell apoptosis through suppression of GLUT3 expression | Â | 25 |
miR-210 | human pulmonary arterial endothelial cells (HPAECs) | cellular metabolism and adaptation to cellular stress | ISCU1/2 | 42 |
miR-23a/b | human P-493 B cells | regulate expression of glutaminase and glutamine metabolism | c-Myc | 6 |
miR-277 | D. melanogaster | a metabolic switch controlling amino acid catabolism | Â | 61 |
miR-27a | 3T3-L1 | suppress adipocyte differentiation | PPARγ | 51 |
 | Male C57BL/6J mice and 3T3-L1 cells | a negative regulator of adipocyte differentiation |  |  |
miR-29b | human kidney cells (HEK293) | control metabolic pathway of amino acid catabolism | mRNA for DBT | 62 |
miR-335 | liver of obese mouse | affects adipocyte differentiation and lipid accumulation | PPAR γ & aP2 | 53 |
miR-33a/b | mouse peritoneal macrophages | regulate both HDL biogenesis in the liver and cellular cholesterol efflux | ABCA1 | 58 |
miR-34a | diabetic db/db mice islets / MIN6B1 cells | sensitization to apoptosis and impaired nutrient-induced secretion | BclII / p53 pathway | 52,68 |
miR-370 | liver of mouse | affects lipid metabolism | Cpt1 α | 54 |
miR-375 | pancreatic endocrine cells (MIN6 cells) | suppressed glucose-induced insulin secretion | Mtpn | 45,76 |
miR-378 | NMuMG cells and NT2196 | reduce tricarboxylic acid cycle gene expression and oxygen consumption as well as increase lactate production | ERRγ and GABPA | 8 |
 | INS-1E cells/primary rat islets | decreased glucose-stimulatory action on insulin gene expression and DNA synthesis |  |  |
 |  | Cell growth | Eef1e1 | 76 |
 |  | cell growth | Cadm1 | 76 |
 |  | negatively regulate cellular growth and proliferation | C1qbp | 76 |
 |  | regulate cell cycle and cellular proliferation | Cav1 / p53 pathway or MAPK pathway | 76,79 |
 |  | angiogenesis and cell proliferation | Id3 / VEGF pathway or MAPK pathway | 76,79 |
 |  | regulate cell growth/survival | Rasd1 / Ras pathway | 76,81 |
 |  | cell-cell signaling | Rgs16 | 76 |
 |  | mitochondrial morphology and cristae structure, cell survival and death | Aifm1 | 76 |
 |  | negative regulation of proliferative activity | HuD | 76,83 |