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Table 1 Summary of miRNA regulation in energy metabolism

From: Roles of microRNA on cancer cell metabolism

miRNA

Tissue / cell lines

miRNA functions

Target gene/Pathway

Reference

miR-103/107

obese mice: ob/ob mice and diet-induced-obese (DIO) C57BL/6J mice

regulate insulin sensitivity

caveolin-1

41

miR-122

primary mouse hepatocytes and AML12

regulator of cholesterol and fatty-acid metabolism

 

23,26,38,49,5054,60

miR-133

293FT cells

decreased GLUT4 expression and reduced insulin-mediated glucose uptake in cardio myocytes

 

31,34

miR-14

Drosophila

regulate fat metabolism

 

36

miR-143

liver of obese mouse models

impairs insulin-stimulated AKT activation and glucose homeostasis

Orp8 / Akt pathway

12,26,35,36, 37,91

miR-146

diabetic db/db mice islets / MIN6B1 cells

cell death

Irak1 & Traf6 / AP-1 pathway

52

miR-15a/16-1

leukemic cell line model (MEG-01) and in primary CLL samples

directly or indirectly affect apoptosis and cell cycle

MCL1, BCL2, ETS1,or JUN

27

miR-195-5p

bladder cancer T24 cells

inhibited cell growth and promoted cell apoptosis through suppression of GLUT3 expression

 

25

miR-210

human pulmonary arterial endothelial cells (HPAECs)

cellular metabolism and adaptation to cellular stress

ISCU1/2

42

miR-23a/b

human P-493 B cells

regulate expression of glutaminase and glutamine metabolism

c-Myc

6

miR-277

D. melanogaster

a metabolic switch controlling amino acid catabolism

 

61

miR-27a

3T3-L1

suppress adipocyte differentiation

PPARγ

51

 

Male C57BL/6J mice and 3T3-L1 cells

a negative regulator of adipocyte differentiation

  

miR-29b

human kidney cells (HEK293)

control metabolic pathway of amino acid catabolism

mRNA for DBT

62

miR-335

liver of obese mouse

affects adipocyte differentiation and lipid accumulation

PPAR γ & aP2

53

miR-33a/b

mouse peritoneal macrophages

regulate both HDL biogenesis in the liver and cellular cholesterol efflux

ABCA1

58

miR-34a

diabetic db/db mice islets / MIN6B1 cells

sensitization to apoptosis and impaired nutrient-induced secretion

BclII / p53 pathway

52,68

miR-370

liver of mouse

affects lipid metabolism

Cpt1 α

54

miR-375

pancreatic endocrine cells (MIN6 cells)

suppressed glucose-induced insulin secretion

Mtpn

45,76

miR-378

NMuMG cells and NT2196

reduce tricarboxylic acid cycle gene expression and oxygen consumption as well as increase lactate production

ERRγ and GABPA

8

 

INS-1E cells/primary rat islets

decreased glucose-stimulatory action on insulin gene expression and DNA synthesis

  
  

Cell growth

Eef1e1

76

  

cell growth

Cadm1

76

  

negatively regulate cellular growth and proliferation

C1qbp

76

  

regulate cell cycle and cellular proliferation

Cav1 / p53 pathway or MAPK pathway

76,79

  

angiogenesis and cell proliferation

Id3 / VEGF pathway or MAPK pathway

76,79

  

regulate cell growth/survival

Rasd1 / Ras pathway

76,81

  

cell-cell signaling

Rgs16

76

  

mitochondrial morphology and cristae structure, cell survival and death

Aifm1

76

  

negative regulation of proliferative activity

HuD

76,83