Table 2 Biomarkers’ conversion rate between paired PT and LNM
Marker | N | Positive in PT | Positive in LNM | Conversion rate PT → LNM | |||
|---|---|---|---|---|---|---|---|
N (%) | N (%) | (−) → (+) N (%) | (+) → (−) N (%) | N (%) | kappa coefficient (95% CI) | ||
mRNA TWIST1 | 29 | 14 (48) | 17 (59) | 9 (31) | 6 (21) | 15 (52) | −0.03 (−0.38-0.33) |
mRNA SNAIL | 29 | 16 (55) | 14 (48) | 3 (10) | 5 (17) | 8 (28) | 0.45 (0.13-0.77) |
mRNA SLUG | 29 | 14 (48) | 15 (52) | 6 (21) | 7 (24) | 13 (45) | 0.1 (−0.26-0.47) |
TWIST1 | 39 | 15 (38) | 17 (44) | 10 (26) | 8 (20) | 18 (46) | 0.05 (−0.26-0.36) |
SNAIL | 38 | 15 (39) | 29 (76) | 17 (45) | 3 (8) | 20 (53) | 0.05 (−0.18-0.29) |
SLUG | 39 | 10 (26) | 7 (18) | 7 (18) | 4 (10) | 11 (28) | 0.18 (−0.16-0.52) |
Vimentin | 42 | 5 (12) | 4 (10) | 1 (2) | 2 (5) | 3 (7) | 0.63 (0.24-1) |
E-cadherin | 40 | 35 (87) | 35 (87) | 0 (0) | 0 (0) | 0 (0) | 1 (1.0-1.0) |
ER | 40 | 23 (57) | 28 (70) | 6 (15) | 1 (3) | 7 (18) | 0.63 (0.39-0.87) |
PgR | 41 | 26 (63) | 32 (78) | 9 (22) | 3 (7) | 12 (29) | 0.31 (0.02-0.6) |
HER2 | 34 | 5 (15) | 6 (18) | 1 (3) | 0 (0) | 1 (3) | 0.89 (0.68-1) |