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Table 2 Biomarkers’ conversion rate between paired PT and LNM

From: Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer

Marker N Positive in PT Positive in LNM Conversion rate PT → LNM
   N (%) N (%) (−) → (+) N (%) (+) → (−) N (%) N (%) kappa coefficient (95% CI)
mRNA TWIST1 29 14 (48) 17 (59) 9 (31) 6 (21) 15 (52) −0.03 (−0.38-0.33)
mRNA SNAIL 29 16 (55) 14 (48) 3 (10) 5 (17) 8 (28) 0.45 (0.13-0.77)
mRNA SLUG 29 14 (48) 15 (52) 6 (21) 7 (24) 13 (45) 0.1 (−0.26-0.47)
TWIST1 39 15 (38) 17 (44) 10 (26) 8 (20) 18 (46) 0.05 (−0.26-0.36)
SNAIL 38 15 (39) 29 (76) 17 (45) 3 (8) 20 (53) 0.05 (−0.18-0.29)
SLUG 39 10 (26) 7 (18) 7 (18) 4 (10) 11 (28) 0.18 (−0.16-0.52)
Vimentin 42 5 (12) 4 (10) 1 (2) 2 (5) 3 (7) 0.63 (0.24-1)
E-cadherin 40 35 (87) 35 (87) 0 (0) 0 (0) 0 (0) 1 (1.0-1.0)
ER 40 23 (57) 28 (70) 6 (15) 1 (3) 7 (18) 0.63 (0.39-0.87)
PgR 41 26 (63) 32 (78) 9 (22) 3 (7) 12 (29) 0.31 (0.02-0.6)
HER2 34 5 (15) 6 (18) 1 (3) 0 (0) 1 (3) 0.89 (0.68-1)
  1. Conversion described as the number (percentage) of discordant cases and kappa coefficient of concordance.