Figure 1
From: Human conditions of insulin-like growth factor-I (IGF-I) deficiency
Schematic structures of IGFs and their receptors. Resemblances between Insulin and IGFs allow them to cross-interactions by which IGFs are able to bind to their own receptors (preferently) but also to Insulin receptor (IR) with a lower specificity. The hybrid receptor shares components from both IR and IGF-IR. * IGF-II can also interact with IGF-IR, hybrid receptor and insulin receptor, with a lower affinity.