Figure 5
From: A gender-related action of IFNbeta-therapy was found in multiple sclerosis
IL6 pathways regulate Th cell differentiation and Th cell network homeostasis in healthy men and women. In health APC IL6 pathways regulate Th cell differentiation and Th cell network homeostasis by the positive linked production of IL6 and IL4 in men, and the negative linked production of IL6 and IL10 cytokines in women. Instead (Figures 3 and 4), in MS untreated patients the relationship between the production of IL6 and IL4 changes from positive to negative in men, while the relationship between the production of IL6 and IL10 changes from negative to positive in women.