Table 1 Sample vocabularies for key AD disease, pathological observations, and tissue concepts, used in the AD IN
From: Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
Alzheimer's Disease sub-types | Pathological observations in AD | Brain regions affected in AD |
|---|---|---|
Alzheimer's Disease | Acute-Phase Reaction | Amygdala |
Early Onset Alzheimer's Disease | Amyloid Deposition | Anterior Thalamic Nucleus |
Early Onset Familial Alzheimer's Disease | Amyloid Fibril Formation | Basal Nucleus of Meynert |
Familial Alzheimer's Disease | Amyloidosis | CA1 region |
Incipient Alzheimer's Disease | Asymmetric Cortical Atrophy | CA2 region |
Late Onset Alzheimer's Disease | Blood Brain Barrier Dysfunction | CA3 region |
Late Onset Sporadic Alzheimer's Disease | Central Nervous System Inflammation | Cholinergic Neuron |
Mid-Stage Alzheimer's Disease | Cerebral Atrophy | Diagonal Band of Broca |
Mild-to-Moderate Alzheimer's Disease | Cholinergic Dysfunction | Entorhinal Cortex |
Moderate Alzheimer's Disease | Corpus Callosum Atrophy | Frontal Lobe |
Moderate-to-Severe Alzheimer's Disease | Dystrophic Neuronal Growth | Hippocampus |
Sporadic Alzheimer's Disease | Glial Inflammation | Inferior Temporal Gyrus |
Severe Alzheimer's Disease | Gliosis | Left Thalamus |
Glucose Hypometabolism | Locus Coeruleus | |
Granulovacuolar Degeneration | Medial Temporal Cortex | |
Hippocampal Neurodegeneration | Parahippocampal Gyrus | |
Inflammation | Parietal Lobe | |
Locus Coeruleus Neuronal Loss | Prefrontal Cortex | |
Mitochondrial Failure | Septal Nucleus | |
Nerve Degeneration | Subiculum | |
Neuritic Plaque Formation | Substantia Innominata | |
Neurofibrillary Degeneration | Superior Temporal Gyrus | |
Neurofibrillary Lesion | Synapse | |
Neurofibrillary Tangle Formation | Temporal Isocortex | |
Neuroinflammation | Temporal Lobe | |
Neuronal Degeneration | Thalamus | |
Neuronal Dysfunction | ||
Neuronal Dystrophy | ||
Neuronal Inclusion Bodies | ||
Neuronal Lesion | ||
Neuronal Loss | ||
Neuronal Necrosis | ||
Neuronal Shrinkage | ||
Occipital Atrophy | ||
Oxidative Damage | ||
Oxidative Stress | ||
Perivascular Amyloidosis | ||
Synapse Dysfunction | ||
Synaptic Degeneration | ||
Synaptic Loss | ||
Synapse Enlargement | ||
Tau Deposition | ||
Tau Phosphorylation | ||
Tau-Mediated Cytotoxicity |