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Table 1 Sample vocabularies for key AD disease, pathological observations, and tissue concepts, used in the AD IN

From: Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

Alzheimer's Disease sub-types Pathological observations in AD Brain regions affected in AD
Alzheimer's Disease Acute-Phase Reaction Amygdala
Early Onset Alzheimer's Disease Amyloid Deposition Anterior Thalamic Nucleus
Early Onset Familial Alzheimer's Disease Amyloid Fibril Formation Basal Nucleus of Meynert
Familial Alzheimer's Disease Amyloidosis CA1 region
Incipient Alzheimer's Disease Asymmetric Cortical Atrophy CA2 region
Late Onset Alzheimer's Disease Blood Brain Barrier Dysfunction CA3 region
Late Onset Sporadic Alzheimer's Disease Central Nervous System Inflammation Cholinergic Neuron
Mid-Stage Alzheimer's Disease Cerebral Atrophy Diagonal Band of Broca
Mild-to-Moderate Alzheimer's Disease Cholinergic Dysfunction Entorhinal Cortex
Moderate Alzheimer's Disease Corpus Callosum Atrophy Frontal Lobe
Moderate-to-Severe Alzheimer's Disease Dystrophic Neuronal Growth Hippocampus
Sporadic Alzheimer's Disease Glial Inflammation Inferior Temporal Gyrus
Severe Alzheimer's Disease Gliosis Left Thalamus
  Glucose Hypometabolism Locus Coeruleus
  Granulovacuolar Degeneration Medial Temporal Cortex
  Hippocampal Neurodegeneration Parahippocampal Gyrus
  Inflammation Parietal Lobe
  Locus Coeruleus Neuronal Loss Prefrontal Cortex
  Mitochondrial Failure Septal Nucleus
  Nerve Degeneration Subiculum
  Neuritic Plaque Formation Substantia Innominata
  Neurofibrillary Degeneration Superior Temporal Gyrus
  Neurofibrillary Lesion Synapse
  Neurofibrillary Tangle Formation Temporal Isocortex
  Neuroinflammation Temporal Lobe
  Neuronal Degeneration Thalamus
  Neuronal Dysfunction  
  Neuronal Dystrophy  
  Neuronal Inclusion Bodies  
  Neuronal Lesion  
  Neuronal Loss  
  Neuronal Necrosis  
  Neuronal Shrinkage  
  Occipital Atrophy  
  Oxidative Damage  
  Oxidative Stress  
  Perivascular Amyloidosis  
  Synapse Dysfunction  
  Synaptic Degeneration  
  Synaptic Loss  
  Synapse Enlargement  
  Tau Deposition  
  Tau Phosphorylation  
  Tau-Mediated Cytotoxicity