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Table 2 Bax/Mcl-1 ratio in controls and OSA patients

From: Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling

Treatment groups Nox (6 hrs) IH (6 cycles) SH (6 hrs) P1 P2
Controls (n=5) 1.97 ± 0.7 0.8 ± 0.5 1.05± 0.6 0.002† 0.04
Controls* (n=3) 2.0 ± 0.4 1.14 ± 0.4 ND 0.09  
Controls pooled (n=8) 1.99 ± 0.3 0.97 ± 0.2 ND 0.001  
OSA (n=7) 1.0 ± 0.5‡ 0.63 ± 0.3 ND 0.09  
  1. Normoxia (Nox), intermittent hypoxia (IH), sustained hypoxia (SH).
  2. * - Healthy controls were investigated in parallel with OSA patients in the Sleep Lab.
  3. ND – not determined. Values represent means ± SD. P1 - statistical significance, IH vs. Normoxia (Nox); P2 - statistical significance, SH vs. Nox. †Once Bonferroni correction was added to compare the effects of IH and SH vs. Nox (for multiple comparisons, values of p<0.017 were considered significant), only the effects of IH remained significant.
  4. ‡−Differences between OSA patients and controls under normoxic conditions, p=0.015. A paired two-tailed t test was used for a single comparison.