TY - JOUR AU - Dyugovskaya, Larissa AU - Polyakov, Andrey AU - Cohen-Kaplan, Victoria AU - Lavie, Peretz AU - Lavie, Lena PY - 2012 DA - 2012/10/22 TI - Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling JO - Journal of Translational Medicine SP - 211 VL - 10 IS - 1 AB - Prolonged neutrophil survival is evident in various cardiovascular and respiratory morbidities, in hypoxic conditions in-vitro and in patients with obstructive sleep apnea (OSA) characterized by nightly intermittent hypoxia (IH). This may lead to persistent inflammation, tissue injury and dysfunction. We therefore investigated by a translational approach the potential contribution of the intrinsic stress-induced mitochondrial pathway in extending neutrophil survival under IH conditions. Thus, neutrophils of healthy individuals treated with IH in-vitro and neutrophils of OSA patients undergoing nightly IH episodes in-vivo were investigated. Specifically, the balance between pro-apoptotic Bax and anti-apoptotic Mcl-1 protein expression, and the potential involvement of p38MAPK and ERK1/2 signaling pathways in the control of Mcl-1 expression were investigated. SN - 1479-5876 UR - https://doi.org/10.1186/1479-5876-10-211 DO - 10.1186/1479-5876-10-211 ID - Dyugovskaya2012 ER -