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Table 3 Intracellular accumulation of DDP in A549 cells, A549/DDP cells and A549/DDP cells treated with control siRNA or ATP7A siRNA respectively

From: Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC)

cells Concentration (μmol/106 cells) P
A549 0.69 ± 0.007  
A549/DDP 0.06 ± 0.002 < 0.001
A549/DDP_Control_siRNA 0.06 ± 0.005  
A549/DDP_ATP7A_siRNA 0.13 ± 0.003 < 0.001
  1. Pt levels were expressed as μmol/1 × 106 cells (A549 cells, A549/DDP cells and A549/DDP cells treated with control siRNA ATP7A siRNA). Experiments were performed in duplicate and the values expressed were the means ± SD of the three independent experiments