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Table 1 Drug sensitivity of A549 and A549/DDP cells to platinum derivatives (DDP, CBDCA and L-OHP)

From: Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC)

  aIC50 (mean ± SD, uM)
Drugs A549 A549/DDP bRI P
DDP 3.79 ± 0.11 29.83 ± 1.25 7.88 < 0.001
CBDCA 45.85 ± 1.24 205.70 ± 3.02 4.49 < 0.001
L-OHP 7.68 ± 0.28 18.07 ± 0.39 2.35 < 0.001
  1. Cells were precultured for 24 hrs at a density of 5*103 cells/well in 96-well multiplates.Cytotoxicity was determined 72 hrs after drug exposure by MTT. a, IC50, inhibitory concentration that kills 50% of cell population. Data represents the mean ± SD of at least three independent experiments performed with 8 wells at each drug concentration tested. b, RI, resistance index calculated as IC50 resistant/IC50 sensitive cell line. SD, standard deviation; DDP, cisplatin; CBDCA, carboplatin; L-OHP, oxaliplatin. P < 0.05 was considered as a significant change in drug sensitivity (Student's t-test)