| aIC50 (mean ± SD, uM) |
---|
Drugs | A549 | A549/DDP | bRI |
P
|
---|
DDP | 3.79 ± 0.11 | 29.83 ± 1.25 | 7.88 | < 0.001 |
CBDCA | 45.85 ± 1.24 | 205.70 ± 3.02 | 4.49 | < 0.001 |
L-OHP | 7.68 ± 0.28 | 18.07 ± 0.39 | 2.35 | < 0.001 |
- Cells were precultured for 24 hrs at a density of 5*103 cells/well in 96-well multiplates.Cytotoxicity was determined 72 hrs after drug exposure by MTT. a, IC50, inhibitory concentration that kills 50% of cell population. Data represents the mean ± SD of at least three independent experiments performed with 8 wells at each drug concentration tested. b, RI, resistance index calculated as IC50 resistant/IC50 sensitive cell line. SD, standard deviation; DDP, cisplatin; CBDCA, carboplatin; L-OHP, oxaliplatin. P < 0.05 was considered as a significant change in drug sensitivity (Student's t-test)