Figure 2 | A (TNF-α, 30 min He, 4 h LPS) | B (TNF-α, 30 min He, 24 h LPS) | C (TNF-α, 60 min He, 4 h LPS) | D (TNF-α, 60 min He, 24 h LPS) | ||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.68 | 12 | 12 | 12 | 0.42 | 12 | 12 | 12 | 0.84 | 6 | 6 | 6 | 0.53 | 6 | 6 | 6 |
T1 | 0.91 | 12 | 12 | 12 | 0.73 | 12 | 12 | 12 | 0.44 | 6 | 6 | 6 | 0.35 | 6 | 6 | 6 |
T2 | 0.73 | 12 | 12 | 12 | 0.52 | 12 | 12 | 12 | 0.06 | 5 | 6 | 5 | 0.50 | 6 | 6 | 6 |
T3 | 0.38 | 12 | 12 | 12 | 0.79 | 12 | 12 | 12 | 0.81 | 5 | 5 | 6 | 0.72 | 6 | 6 | 6 |
T4 | 0.27 | 12 | 12 | 12 | 0.73 | 12 | 12 | 12 | 0.44 | 5 | 5 | 6 | 0.53 | 6 | 6 | 6 |
T5 | 0.52 | 12 | 12 | 12 | 0.68 | 12 | 12 | 12 | 0.56 | 6 | 6 | 6 | 0.70 | 6 | 6 | 6 |
E (IL-6, 30 min He, 4 h LPS) | F (IL-6, 30 min He, 24 h LPS) | G (IL-6, 60 min He, 4 h LPS) | H (IL-6, 60 min He, 24 h LPS) | |||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.91 | 12 | 12 | 12 | 0.65 | 10 | 10 | 11 | 1.00 | 6 | 6 | 6 | 0.09 | 6 | 6 | 6 |
T1 | 0.83 | 11 | 11 | 12 | 0.08 | 11 | 11 | 12 | 0.16 | 6 | 6 | 6 | 0.44 | 6 | 6 | 6 |
T2 | 0.42 | 12 | 12 | 12 | 0.62 | 10 | 10 | 12 | 0.44 | 6 | 6 | 6 | 0.84 | 6 | 6 | 6 |
T3 | 0.91 | 12 | 12 | 12 | 0.11 | 11 | 11 | 11 | 1.00 | 4 | 4 | 5 | 1.00 | 6 | 6 | 6 |
T4 | 0.76 | 11 | 12 | 11 | 0.23 | 10 | 10 | 12 | 1.00 | 5 | 6 | 5 | 0.44 | 6 | 6 | 6 |
T5 | 1.00 | 12 | 12 | 12 | 0.77 | 11 | 11 | 11 | 0.69 | 5 | 6 | 5 | 0.69 | 6 | 6 | 6 |
Figure 3 | A (IL-1β, 30 min He, 4 h LPS) | B (IL-1β, 30 min He, 24 h LPS) | C (IL-1β, 60 min He, 4 h LPS) | D (IL-1β, 60 min He, 24 h LPS) | ||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.30 | 12 | 12 | 12 | 0.28 | 12 | 12 | 12 | 1.00 | 6 | 6 | 6 | 1.00 | 5 | 6 | 5 |
T1 | 0.42 | 12 | 12 | 12 | 0.42 | 12 | 12 | 12 | 0.56 | 6 | 6 | 6 | 0.44 | 6 | 6 | 6 |
T2 | 0.34 | 12 | 12 | 12 | 0.30 | 12 | 12 | 12 | 0.19 | 6 | 6 | 6 | 0.31 | 6 | 6 | 6 |
T3 | 0.13 | 12 | 12 | 12 | 0.97 | 12 | 12 | 12 | 0.44 | 5 | 5 | 5 | 0.44 | 6 | 6 | 6 |
T4 | 0.70 | 11 | 12 | 11 | 0.97 | 12 | 12 | 12 | 1.00 | 6 | 6 | 6 | 1.00 | 6 | 6 | 6 |
T5 | 1.00 | 12 | 12 | 12 | 0.34 | 12 | 12 | 12 | 0.69 | 6 | 6 | 6 | 0.69 | 6 | 6 | 6 |
E (IL-8, 30 min He, 4 h LPS) | F (IL-8, 30 min He, 24 h LPS) | G (IL-8, 60 min He, 4 h LPS) | H (IL-8, 60 min He, 24 h LPS) | |||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.34 | 12 | 12 | 12 | 0.46 | 10 | 10 | 10 | 0.22 | 6 | 6 | 6 | 0.22 | 6 | 6 | 6 |
T1 | 0.34 | 12 | 12 | 12 | 0.47 | 9 | 10 | 9 | 0.31 | 6 | 6 | 6 | 0.84 | 6 | 6 | 6 |
T2 | 0.20 | 12 | 12 | 12 | 0.31 | 10 | 10 | 10 | 0.56 | 6 | 6 | 6 | 0.44 | 6 | 6 | 6 |
T3 | 0.51 | 12 | 12 | 12 | 0.43 | 11 | 11 | 11 | 0.44 | 6 | 6 | 6 | 0.16 | 6 | 6 | 6 |
T4 | 0.91 | 11 | 12 | 11 | 0.50 | 10 | 11 | 10 | 0.84 | 6 | 6 | 6 | 0.44 | 6 | 6 | 6 |
T5 | 0.97 | 12 | 12 | 12 | 0.13 | 10 | 10 | 11 | 1.00 | 6 | 6 | 6 | 0.84 | 6 | 6 | 6 |
Figure 4 | A (TNF-α, 30 min He, 4 h LTA) | B (TNF-α, 30 min He, 24 h LTA) | C (IL-6, 30 min He, 4 h LTA) | D (IL-6, 30 min He, 24 h LTA) | ||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.90 | 12 | 12 | 12 | 0.68 | 12 | 12 | 12 | 0.24 | 11 | 12 | 11 | 0.55 | 11 | 11 | 12 |
T1 | 0.68 | 12 | 12 | 12 | 0.76 | 12 | 12 | 12 | 0.89 | 11 | 12 | 11 | 0.02* | 11 | 11 | 12 |
T2 | 0.73 | 12 | 12 | 12 | 0.79 | 12 | 12 | 12 | 0.05 | 11 | 11 | 11 | 0.64 | 11 | 11 | 12 |
T3 | 0.30 | 12 | 12 | 12 | 0.94 | 12 | 12 | 12 | 0.24 | 11 | 12 | 11 | 0.24 | 11 | 11 | 12 |
T4 | 0.20 | 11 | 12 | 11 | 0.38 | 11 | 12 | 11 | 0.07 | 11 | 11 | 12 | 0.05 | 11 | 11 | 12 |
T5 | 0.97 | 12 | 12 | 12 | 0.91 | 12 | 12 | 12 | 0.41 | 11 | 12 | 12 | 0.32 | 11 | 11 | 12 |
E (IL-1β, 30 min He, 4 h LTA) | F (IL-1β, 30 min He, 24 h LTA) | G (IL-8, 30 min He, 4 h LTA) | H (IL-8, 30 min He, 24 h LTA) | |||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.89 | 11 | 11 | 12 | 1.00 | 11 | 11 | 12 | 0.34 | 12 | 12 | 12 | 0.19 | 8 | 8 | 10 |
T1 | 0.62 | 12 | 12 | 12 | 0.44 | 11 | 11 | 12 | 0.34 | 12 | 12 | 12 | 0.63 | 8 | 9 | 8 |
T2 | 0.34 | 12 | 12 | 12 | 0.31 | 11 | 11 | 12 | 0.20 | 12 | 12 | 12 | 0.74 | 10 | 10 | 11 |
T3 | 0.97 | 12 | 12 | 12 | 0.44 | 11 | 11 | 12 | 0.51 | 12 | 12 | 12 | 0.81 | 9 | 9 | 10 |
T4 | 0.38 | 12 | 12 | 12 | 1.00 | 11 | 11 | 12 | 0.91 | 11 | 12 | 11 | 0.07 | 11 | 11 | 11 |
T5 | 1.00 | 11 | 11 | 11 | 0.69 | 11 | 11 | 12 | 0.97 | 12 | 12 | 12 | 0.20 | 11 | 11 | 11 |
Figure 5 | A (IL-2, 30 min He, 4 h TCS) | B (IL-2, 30 min He, 24 h TCS) | C (IFN- Υ, 30 min He, 4 h TCS) | D (IFN- Υ, 30 min He, 24 h TCS) | ||||||||||||
p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | p | n | n He | n Air | |
T0 | 0.76 | 11 | 11 | 11 | 0.83 | 11 | 11 | 11 | 0.92 | 11 | 11 | 11 | 0.16 | 11 | 11 | 11 |
T1 | 0.83 | 11 | 11 | 11 | 0.97 | 11 | 11 | 11 | 1.00 | 11 | 11 | 11 | 0.16 | 10 | 11 | 10 |
T2 | 0.58 | 11 | 11 | 11 | 0.46 | 11 | 11 | 11 | 0.01* | 11 | 11 | 11 | 0.91 | 10 | 10 | 10 |
T3 | 0.76 | 11 | 11 | 11 | 0.85 | 11 | 11 | 11 | 0.38 | 11 | 11 | 11 | 0.16 | 10 | 12 | 10 |
T4 | 0.28 | 11 | 11 | 11 | 0.10 | 11 | 11 | 11 | 0.13 | 11 | 11 | 11 | 0.85 | 10 | 12 | 10 |
T5 | 0.28 | 11 | 11 | 11 | 0.58 | 11 | 11 | 11 | 1.00 | 11 | 11 | 11 | 0.01* | 10 | 11 | 10 |