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Table 2 Drug concentrations tested in NCI-H295R and SW-13 MCA 1

From: Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening

Drugs

IC502(μM)

Maximum serum level (μM)

Conc3. tested in MCA (μM)

Ratio of tested conc. to IC50

Bortezomib

0.34

0.31

3.4, 0.34, 0.17, 0.03

10x, 1x, 0.5x, 0.1x

Ouabain

0.08

0.13

0.8, 0.16, 0.08

10x, 2x, 1x

Methotrexate

0.02

10-100

2, 1, 0.2

100x, 50x, 10x

Pyrimethamine

0.75

8.0

7.5, 3.7

10x, 5x

  1. 1MCA: 3-dimensional multicellular aggregates.
  2. 2IC50: half maximal inhibitory concentration.
  3. 3Conc: concentrations.