Matrix Metalloproteinase-dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis

Table 2 Biochemical markers measured in serum on day 7 and 22 compared to baseline

	Time point	Control	CIA	P-value
C1M	Day 7	9.939 ± 7.963	15.63 ± 9.461	0.6038
C1M	Day 22	9.283 ± 7.216	51.2 ± 8.947	0.0068 **
C2M	Day 7	5.376 ± 10.15	12.39 ± 11.54	0.5490
C2M	Day 22	−7.593 ± 7.610	31.92 ± 10.51	0.0068 **
CTX-II	Day 7	−38.89 ± 41.61	−81.54 ± 6.355	0.7487
CTX-II	Day 22	−87.71 ± 12.29	10963 ± 5236	0.0004 ***
C3M	Day 7	−1.609 ± 4.95	4.312 ± 8.117	0.6608
C3M	Day 22	0.4491 ± 3.92	39.73 ± 5.447	<0.0001 ***
P1NP	Day 7	−14.72 ± 9.157	−19.59 ± 13.53	0.4002
P1NP	Day 22	−20.67 ± 5.433	,35.59 ± 7.097	0.2176
P2NP	Day 7	2.327 ± 13.29	−4.001 ± 5.772	0.8633
P2NP	Day 22	3.346 ± 11.57	−4.766 ± 9.643	0.8534
P3NP	Day 7	−1.829 ± 3.588	−8.746 ± 2.936	0.3562
P3NP	Day 22	2.334 ± 2.849	6.045 ± 2.790	0.5288

The CIA (n = 10) and control groups (n = 10) were compared by Man-Whitney t-test on both days. All statistical analyses were calculated based on baseline corrected values. Data are shown as mean ± SEM and significance levels as *: P < 0.05, **: P < 0.01, ***: P < 0.001.

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